About this Research Topic
It is already being known that miRNAs are considered novel biomarkers for infectious and inherited diseases. They are being used to design different types of vaccines for emerging infectious diseases. Differential miRNAs expression is linked to various anomalies in the body. Single nucleotide polymorphisms (SNPs) are one of the most common genetic variations in miRNAs that are associated with both human and animal diseases. Keeping in view the important role of SNPs in miRNAs genes causing infectious and inherited diseases, the current issue will highlight the effect of functional miRNA-related SNPs on their clinical consequences.
Mature miRNAs are highly stable in extracellular fluids and may act as biomarkers for infectious and inherited diseases in mammals. They also play a pivotal role in fortifying host immune responses during microbial infections through regulating proteins involved in innate and adaptive immune pathways utilized by bacterial effectors. Several polymorphic miRNAs have been reported to contribute to the risk of infectious and inherited diseases. Alteration in miRNA genes leads to severe infectious and inherited diseases. This special issue of the journal will cover the following topics.
-Functional analyses of novel miRNA SNPs associated with human and animal diseases
-Consequences of SNPs in miRNA genes and their potential to serve as diagnostics biomarkers.
-Novel bioinformatics approaches to identify the potential SNPs in miRNA binding regions
-Impacts of mirQTLs on miRNA levels in infectious and inherited diseases
-The roles of miRSNPs on microbiome compositions associated with human diseases
Keywords: MicroRNA, Polymorphism, Infectious Disease, Inherited Disease, Sinle Nucleotide Polymorphism, mirQTLs, miRSNPs, host-immune response, noncoding RNA, RISC, human genome, RNA, Intronic region, mutation, non-coding genome
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