Hyperproliferative skin disorders includes pathologies characterized by uncontrolled proliferation of skin cells such as psoriasis, skin dermatoses and non-melanoma skin cancers, which could be determined by environmental factors, DNA alterations, immune response dysregulation or a combination of the aforementioned. These factors lead to the development of lesions with different levels of severity and, in some conditions the heterogeneity of patients’ response makes basic and translational research essential for the development of novel therapeutic strategies.
In particular, psoriasis is a complex hyperproliferative and immune skin disorder with both environmental and genetic components. Psoriasis occurs worldwide, affecting people of all ages. Its pathogenesis is not completely understood and it is a subject of intensive investigations, with particular attention to the mutual role of keratinocytes and immune cells. Highly influenced by external as well as genetic factors, the atopic dermatitis also involves the development of a strong immune component, with a prevalence of Th2-response in the acute phase, and important epidermal barrier defects. Recently, it has been shown that the incidence of AD is increasing in the developed countries, affecting up to 20% of children and 1-3% of adults. Therefore, the identification of risk factors and novel molecular targets are of great importance. Another example of hyperproliferative disorders are non-melanoma skin cancers (NMSC) which represent one of the most common cancers in the world, with a raising incidence every year as well as an increase in the number of deaths. The two most common type of NMSC are the basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), both of which arise from epidermal keratinocytes of the basal or squamous layers respectively. Several tumor suppressor genes and proto-oncogenes have been identified as associated with the development of such lesions. However, the identification of novel molecular biomarkers or altered gene networks will give a key mean through which the development of more effective and accessible therapies could be possible.
With this Research Topic, we would like to provide an update on the latest research efforts on the hyperproliferative skin conditions, including:
• the identification of novel molecular networks
• biomarkers or signalling pathways
• novel in vitro tridimensional healthy/pathological reconstructs or in vivo models for the study of skin diseases.
Therefore, we would like to invite experts in these fields, including dermatological researchers, cancer biologists, and immunologists, to submit original articles and reviews reporting all the latest exciting discoveries.
Hyperproliferative skin disorders includes pathologies characterized by uncontrolled proliferation of skin cells such as psoriasis, skin dermatoses and non-melanoma skin cancers, which could be determined by environmental factors, DNA alterations, immune response dysregulation or a combination of the aforementioned. These factors lead to the development of lesions with different levels of severity and, in some conditions the heterogeneity of patients’ response makes basic and translational research essential for the development of novel therapeutic strategies.
In particular, psoriasis is a complex hyperproliferative and immune skin disorder with both environmental and genetic components. Psoriasis occurs worldwide, affecting people of all ages. Its pathogenesis is not completely understood and it is a subject of intensive investigations, with particular attention to the mutual role of keratinocytes and immune cells. Highly influenced by external as well as genetic factors, the atopic dermatitis also involves the development of a strong immune component, with a prevalence of Th2-response in the acute phase, and important epidermal barrier defects. Recently, it has been shown that the incidence of AD is increasing in the developed countries, affecting up to 20% of children and 1-3% of adults. Therefore, the identification of risk factors and novel molecular targets are of great importance. Another example of hyperproliferative disorders are non-melanoma skin cancers (NMSC) which represent one of the most common cancers in the world, with a raising incidence every year as well as an increase in the number of deaths. The two most common type of NMSC are the basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), both of which arise from epidermal keratinocytes of the basal or squamous layers respectively. Several tumor suppressor genes and proto-oncogenes have been identified as associated with the development of such lesions. However, the identification of novel molecular biomarkers or altered gene networks will give a key mean through which the development of more effective and accessible therapies could be possible.
With this Research Topic, we would like to provide an update on the latest research efforts on the hyperproliferative skin conditions, including:
• the identification of novel molecular networks
• biomarkers or signalling pathways
• novel in vitro tridimensional healthy/pathological reconstructs or in vivo models for the study of skin diseases.
Therefore, we would like to invite experts in these fields, including dermatological researchers, cancer biologists, and immunologists, to submit original articles and reviews reporting all the latest exciting discoveries.
