The Neural Economy Hypothesis: Changes with Aging and Disease to Cones and other Central Nervous System Visual Neurons

  • 5,422

    Total Downloads

  • 26k

    Total Views and Downloads

Download PDFDownload EPUB

Submit your idea

Select the journal/section where you want your idea to be submitted:

Submit your manuscript summarySubmit your manuscript

About this Research Topic

Submission closed

Background

Photoreceptors and other central nervous system cells are considered post-mitotic and at their maximum numbers before birth. To provide decades of vision, these neurons must have inherent repair processes and be supported and renewed by glial and other cells. There are limitations to the extent of support available to photoreceptors, especially given their high metabolic rates, the assault by incident light on the retina, and the need for optical clarity that constrains the numbers and locations of blood vessels. Further, these support systems can fail with aging and disease, creating a harsh microenvironment for extended cone survival. Cones have a remarkable ability to survive, compared with rods, but with alterations in their structure and function, enabling them to stay connected in their circuitry to provide at least some vision. Improving the microenvironment in aging and disease has the potential to preserve cones and visual system circuitry, thereby preserving vision.

The remarkable resiliency of cones, and possibly other visual system neurons, has gone largely unappreciated. It is well known that cones develop long stacks of outer segments to capture light, but the length greatly increases after birth or in adulthood after retinal detachment. Unfortunately, much of the histology for several of the human disease such as age-related macular degeneration is heavily weighted towards very old eyes and end-stage disease. New technologies have enabled in vivo assessments of photoreceptor health with the added advantages of enabling investigations of younger subjects with earlier stage disease and longitudinal studies of disease progression. This special issue will solicit articles that carefully inspect the photoreceptor microenvironment in health, disease, treatment, and aging, using a variety of techniques including histology and in vivo imaging both in human eyes and visual pathways, as well as animal models. Differences between cones and rods, and general properties of visual system neurons will be sought. We expect this issue will fill a gap in recent literature to better understand photoreceptor survival within the retinal microenvironment and how this microenvironment sustains vision throughout a lifetime.

We welcome Original Research, Methods, Review, Mini Review, Hypothesis and Theory, Perspective, Clinical Trial, Case Report, Conceptual Analysis, Data Report, Brief Research Report, General Commentary, Opinion, Technology and Code, on the following subtopics:

• Cone and other visual system neuron survival and function in aging and disease: in vivo or ex vivo human or animal model; structure and/or function; remodeling
• Comparing two diseases; aging vs. disease; comparisons with other measures such as vascular data
• Alteration of neural cells or their microenvironment by gene therapy, stem cell transplantation, or pharmacological agents: human data including clinical trials, surgery or drug therapy, planned or serendipitous; or animal models
• Re-analysis of histological data with cone cell bodies or other visual neurons, early vs. end-stage changes to glia, distinguishing neural vs. glial (Mueller) cell bodies or cones vs. rods
• Technology, code and/or datasets used to assess cone or other visual system neuron numbers, distribution, layer thicknesses
• Imaging and electrophysiology techniques or models


Dr. Morgan’s lab receives financial support from AGTC. Dr. Elsner is the CEO and founder of Aeon Imaging. The other Topic Editors declare no competing interests with regards to the Research Topic theme.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Participating Journals

Impact

  • 26kTopic views
  • 19kArticle views
  • 5,422Article downloads
View impact