From a structural point a view, the cytoskeleton has been classically described in relation to its polymerization and depolymerization balance via the availability of monomers/heterodimers and regulators such as; adaptors, chaperones, kinases and phosphatases. However, the dynamic features of the cytoskeletal structures are highly controlled by extracellular cues and intrinsic processes including the cell cycle. Cells with high capacity of regulating their cytoskeleton adapt better to changes in their environment. Thus the dynamics of the cytoskeleton is directly related to the regulation of molecules and organelle polarization and function. Increasing evidence continues to illustrate the relevant role of fine-tuning the cytoskeleton in cell competition, resulting in selection during processes including, for instance, organ development, tumor growth and immune responses.
The intracellular organization and adoption of different, polarized shapes constitute the basis for specialized cellular functions, such as migration and directed secretion. Indeed, intracellular compartmentalization allows control of cell metabolism, as observed for mitochondrial contacts with the endoplasmic reticulum and peroxisomes, and the Golgi Apparatus. Regulation of organelle and cell polarization requires specific control of polarized anterograde and retrograde traffic of vesicles.
This Research Topic will address physiological and pathological regulation of cytoskeleton dynamics and organelle function during tissue development, tumorigenesis, and immune responses. We welcome submissions of the following article types: Brief Research Report, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, and Review that fall under the following aspects:
• Propagation of plasma membrane signaling through cytoskeleton dynamics
• De novo synthesis of cytoskeleton components during cell polarization events
• Cytoskeletal dynamics regulating cell division and polarization
• Inter-organelle interaction regulated by Cystokeleton dynamics
• Regulation of cell polarization by cytoskeleton-organelle contacts
From a structural point a view, the cytoskeleton has been classically described in relation to its polymerization and depolymerization balance via the availability of monomers/heterodimers and regulators such as; adaptors, chaperones, kinases and phosphatases. However, the dynamic features of the cytoskeletal structures are highly controlled by extracellular cues and intrinsic processes including the cell cycle. Cells with high capacity of regulating their cytoskeleton adapt better to changes in their environment. Thus the dynamics of the cytoskeleton is directly related to the regulation of molecules and organelle polarization and function. Increasing evidence continues to illustrate the relevant role of fine-tuning the cytoskeleton in cell competition, resulting in selection during processes including, for instance, organ development, tumor growth and immune responses.
The intracellular organization and adoption of different, polarized shapes constitute the basis for specialized cellular functions, such as migration and directed secretion. Indeed, intracellular compartmentalization allows control of cell metabolism, as observed for mitochondrial contacts with the endoplasmic reticulum and peroxisomes, and the Golgi Apparatus. Regulation of organelle and cell polarization requires specific control of polarized anterograde and retrograde traffic of vesicles.
This Research Topic will address physiological and pathological regulation of cytoskeleton dynamics and organelle function during tissue development, tumorigenesis, and immune responses. We welcome submissions of the following article types: Brief Research Report, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, and Review that fall under the following aspects:
• Propagation of plasma membrane signaling through cytoskeleton dynamics
• De novo synthesis of cytoskeleton components during cell polarization events
• Cytoskeletal dynamics regulating cell division and polarization
• Inter-organelle interaction regulated by Cystokeleton dynamics
• Regulation of cell polarization by cytoskeleton-organelle contacts
