Ototoxicity is a type of toxicity that mainly affects the inner ear. Cochlea and vestibular organs might be affected by ototoxicity either selectively or concurrently. People with ototoxicity suffer from hearing loss, tinnitus, vertigo, or a combination of these. Among the well-known ototoxic substances, we find organic solvents (e.g., toluene, xylene, styrene) and medicinal products, such as loop diuretics, aminoglycoside antibiotics, or platinum-based chemotherapeutics.
In recent years, clinical reports started to point at other types of drugs contributing to ototoxicity. All these drugs have one thing in common - they are used for the treatment of chronic diseases such as heart conditions, gastroesophageal reflux disease, HIV infection, and conditions associated with chronic pain. Also, among the emerging ototoxic drugs, there are synthetic opiates and phosphodiesterase-5 (PDE5) inhibitors, better known under the trade name Viagra.
In this Research Topic of Frontiers in Neurology Neuro-Otology, we would like to consolidate the contemporary knowledge on the emerging ototoxic drugs, on the epidemiology of ototoxicity induced by these drugs, on the types of ototoxicity they cause, and on the pathomechanisms behind.
We feel that the community deserves a comprehensive update on the emerging ototoxic drugs. Both clinical and basic research is welcome.
We welcome contributions regarding ototoxicity associated with the use of :
o proton pump inhibitors
o reverse transcriptase inhibitors
o beta-blockers
o cyclosporine A
o biologics
o antibiotics other than aminoglycosides
o phosphodiesterase-5 (PDE5) inhibitors
o non-steroidal anti-inflammatory drugs
o Novel therapies for ototoxicity
Ototoxicity is a type of toxicity that mainly affects the inner ear. Cochlea and vestibular organs might be affected by ototoxicity either selectively or concurrently. People with ototoxicity suffer from hearing loss, tinnitus, vertigo, or a combination of these. Among the well-known ototoxic substances, we find organic solvents (e.g., toluene, xylene, styrene) and medicinal products, such as loop diuretics, aminoglycoside antibiotics, or platinum-based chemotherapeutics.
In recent years, clinical reports started to point at other types of drugs contributing to ototoxicity. All these drugs have one thing in common - they are used for the treatment of chronic diseases such as heart conditions, gastroesophageal reflux disease, HIV infection, and conditions associated with chronic pain. Also, among the emerging ototoxic drugs, there are synthetic opiates and phosphodiesterase-5 (PDE5) inhibitors, better known under the trade name Viagra.
In this Research Topic of Frontiers in Neurology Neuro-Otology, we would like to consolidate the contemporary knowledge on the emerging ototoxic drugs, on the epidemiology of ototoxicity induced by these drugs, on the types of ototoxicity they cause, and on the pathomechanisms behind.
We feel that the community deserves a comprehensive update on the emerging ototoxic drugs. Both clinical and basic research is welcome.
We welcome contributions regarding ototoxicity associated with the use of :
o proton pump inhibitors
o reverse transcriptase inhibitors
o beta-blockers
o cyclosporine A
o biologics
o antibiotics other than aminoglycosides
o phosphodiesterase-5 (PDE5) inhibitors
o non-steroidal anti-inflammatory drugs
o Novel therapies for ototoxicity
