About this Research Topic
From now on, such toxicogenomic approaches using organoids with variously differentiated cell types should be essential for bridging between experimental data and human cancers. In recent international toxicology conferences, presentations on organoid-based studies for molecular mechanisms of drug toxicities using multi-omics approaches are also increasing. Organoid systems can be established from animals/human tissues, and human iPSCs. In general, human tissue-derived or human iPSCs-derived organoids are considered advantageous for evaluation of drug toxicities and risks of environmental agents. However, it is necessary to consider individual variations in the use of human-originated organoids. On the other hand, not only mouse tissue-derived organoids but also organoids from other animal species are recently cultured and promised to be utilized for evaluation of species differences in chemical/drug reactions.
The aim of this Research Topic is to highlight novel approaches for the elucidation of the mode-of-action of toxicologic effects of drugs and environmental factors for human health via the collaboration between organoid-based technologies and toxicogenomics.
This research topic welcomes articles related to the following areas:
· Use of organoid-based in vitro models to conduct toxicologic and carcinogenic evaluations for risk assessment of environmental agents
· Novel approaches for the elucidation of the mode-of-action of toxicologic effects of drugs and environmental factors
· Use of toxicogenomics approaches to evaluate individual variations in the use of human-originated organoids
· Toxicogenomics approaches using organoids with variously differentiated cell types to bridge between experimental data and human cancers.
· Use of organoids for evaluation of metabolism of drugs and environmental agents
· Preclinical disease models using organoids for drug discovery
Keywords: toxicogenomics, organoids, cell-based, in vitro, cancer models, cell models, organotypic, toxicity, drug development
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.