RNA Sequencing in Clinical Oncology for Metabolism and Immunity

237.6K

views

351

authors

43

articles

Editors

4

Qingdao University, The Affiliated Qingdao Central Hospital of Qingdao University

The Affiliated Hospital of Qingdao University

Anton A. Buzdin

European Organisation for Research and Treatment of Cancer

University of California, Los Angeles

Impact

Fetching...

About

Tumor cells exhibit an upregulation in glycolysis, glycogen metabolism, and gluconeogenesis as opposed to normal cells. The metabolic reprogramming underlying the Warburg effect and other changes in glucose metabolism are driven by several oncogenes and tumor suppressors. Immunotherapies based on cancer metabolism have been developed but have yet to show success in clinical trials. RNA sequencing (RNAseq) is one of the most commonly used techniques in life sciences, and has been widely used in cancer research. Driven by various biological and technical questions, the techniques of RNAseq have progressed rapidly from bulk RNAseq, laser-captured micro-dissected RNAseq, and single-cell RNAseq to digital spatial RNA profiling, spatial transcriptomics, and direct in situ sequencing.

RNA sequencing in clinical oncology includes bulk RNA-seq, single cell RNA-seq and spatial RNA-seq.We anticipate that bulk RNAseq, among the three, will remain the primary choice for clinical oncology in the near future. The application of single cell sequencing will be expanded when it becomes more cost-effective, and the technologies with spatial content will be the final destiny in precision oncology.

In this Research Topic, we aim to discuss the application of RNA sequencing in clinical oncology for metabolism and immunity. We welcome submissions of Original Research papers and Reviews focusing on but not limited to:
- RNA-Seq based applications for cancer diagnostics and theranostics in metabolism and immunity
- Genome-wide approaches for clinical oncology in metabolism and immunity
- High throughput RNA/Transcriptome approaches in cancer molecular diagnostics
- RNA-Seq for predicting response to targeted therapeutics and chemotherapy regimens
- RNA-Seq for predicting response to immunotherapeutics
- RNA-Seq for predicting response to radiation therapy

Tumor cells exhibit an upregulation in glycolysis, glycogen metabolism, and gluconeogenesis as opposed to normal cells. The metabolic reprogramming underlying the Warburg effect and other changes in glucose metabolism are driven by several oncogenes and tumor suppressors. Immunotherapies based on cancer metabolism have been developed but have yet to show success in clinical trials. RNA sequencing (RNAseq) is one of the most commonly used techniques in life sciences, and has been widely used in cancer research. Driven by various biological and technical questions, the techniques of RNAseq have progressed rapidly from bulk RNAseq, laser-captured micro-dissected RNAseq, and single-cell RNAseq to digital spatial RNA profiling, spatial transcriptomics, and direct in situ sequencing.

RNA sequencing in clinical oncology includes bulk RNA-seq, single cell RNA-seq and spatial RNA-seq.We anticipate that bulk RNAseq, among the three, will remain the primary choice for clinical oncology in the near future. The application of single cell sequencing will be expanded when it becomes more cost-effective, and the technologies with spatial content will be the final destiny in precision oncology.

In this Research Topic, we aim to discuss the application of RNA sequencing in clinical oncology for metabolism and immunity. We welcome submissions of Original Research papers and Reviews focusing on but not limited to:
- RNA-Seq based applications for cancer diagnostics and theranostics in metabolism and immunity
- Genome-wide approaches for clinical oncology in metabolism and immunity
- High throughput RNA/Transcriptome approaches in cancer molecular diagnostics
- RNA-Seq for predicting response to targeted therapeutics and chemotherapy regimens
- RNA-Seq for predicting response to immunotherapeutics
- RNA-Seq for predicting response to radiation therapy

Download ebook

Share

Editors

Qingdao University, The Affiliated Qingdao Central Hospital of Qingdao University

The Affiliated Hospital of Qingdao University

Anton A. Buzdin

European Organisation for Research and Treatment of Cancer

University of California, Los Angeles

Impact

237,552 Total views

148,341 Article views

86,485 Article downloads

2,726 Topic views

Published In

Journal Thumbnail

Frontiers in Oncology

Pharmacology of Anti-Cancer Drugs, Cancer Genetics

Journal Thumbnail

Frontiers in Pharmacology

Pharmacology of Anti-Cancer Drugs

Journal Thumbnail

Frontiers in Genetics

Cancer Genetics

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic