Stem Cells and Cardiovascular Diseases

148.1K

views

220

authors

29

articles

Stem Cells and Cardiovascular Diseases

148.1K

views

220

authors

29

articles

Editorial

28 February 2022

Editorial: Stem Cells and Cardiovascular Diseases

Miao Yu

,

Feng Lan

,

Ming-Tao Zhao

,

Lei Ye

and

Shijun Hu

2,133 views

0 citations

Editors

4

Shijun Hu

Soochow University

Lei Ye

University of Alabama at Birmingham

Mingtao Zhao

Nationwide Children's Hospital

Feng Lan

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Impact

Fetching...

About

Cardiovascular disease (CVD) is a broad medical nomenclature used to describe a group of conditions that affect heart or blood vessels. Despite great advances in cardiovascular biology and medical therapy, CVDs are still the major cause of mortality and morbidity worldwide and have consistently been an important public health issue. Stem cells, especially induced pluripotent stem cells and embryonic stem cells, have emerged as attractive cell source to obtain cardiovascular cells and bioactive materials. They have great potential applications, including drug discovery, toxicity screening, disease modeling, cell or cell-free therapies.

Lessons from embryology offer important insights into the development of stem cell derived cardiovascular cells (cardiomyocytes, endothelial cells, etc). However, hurdles regarding heterogenicity, immaturity, tumorigenesis, grafting cell death, immune rejection and arrhythmogenesis need to be overcome in preclinical and clinical practice. This Research Topic aims to highlight the novel studies and strategies that might overcome current obstacles in cardiovascular translational medicine and their potential applications.

Areas to be covered in this Research Topic may include, but are not limited to:
• Stem cells and differentiation of cardiovascular cells
• Stem cells and cardiovascular repair
• Stem cells and cardiovascular disease modelling
• Stem cells and cardiovascular drug development and safety assay
• Stem cells and cardiac organoid and tissue engineering
• Stem cell derived bioactive materials (such as exosome) and heart

Download ebook

PDF

EPUB

Share

Editors

Shijun Hu

Soochow University

Lei Ye

University of Alabama at Birmingham

Mingtao Zhao

Nationwide Children's Hospital

Feng Lan

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Impact

148,060 Total views

104,268 Article views

41,273 Article downloads

2,519 Topic views

Published In

Frontiers in Cell and Developmental Biology

Stem Cell Research

Frontiers in Genetics

Stem Cell Research

Frontiers in Oncology

Stem Cell Research

Frontiers in Bioengineering and Biotechnology

Stem Cell Research

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic