Heart Valve Biomechanics and Mechanobiology

33.8K

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67

authors

9

articles

Heart Valve Biomechanics and Mechanobiology

33.8K

views

67

authors

9

articles

Editors

3

Joshua D Hutcheson

Florida International University

Emory University

University of Toronto

Impact

About

The appropriate biomechanical function of dynamic heart valve tissues relies on a precise extracellular matrix microarchitecture. Specialized, heterogeneous cell populations within the tissues actively maintain the extracellular matrix structure. Altered biomechanical conditions can cause mechanotransductive cellular responses that result in degradation and synthesis of extracellular matrix components. The remodeled extracellular matrix changes the tissue biomechanics. During heart valve development, this biomechanics-mechanobiology feedback leads to tissue patterning and maturation. However, poor recapitulation of these developmental mechanisms in adult tissues leads to a variety of valvular diseases, which compromise cardiac function and can lead to heart failure. In this Research Topic, we invite contributions that enhance our understanding of heart valve biomechanics and mechanobiology. Reviews and original manuscript contributions may focus on heart valve development, homeostasis, and/or disease.

The appropriate biomechanical function of dynamic heart valve tissues relies on a precise extracellular matrix microarchitecture. Specialized, heterogeneous cell populations within the tissues actively maintain the extracellular matrix structure. Altered biomechanical conditions can cause mechanotransductive cellular responses that result in degradation and synthesis of extracellular matrix components. The remodeled extracellular matrix changes the tissue biomechanics. During heart valve development, this biomechanics-mechanobiology feedback leads to tissue patterning and maturation. However, poor recapitulation of these developmental mechanisms in adult tissues leads to a variety of valvular diseases, which compromise cardiac function and can lead to heart failure. In this Research Topic, we invite contributions that enhance our understanding of heart valve biomechanics and mechanobiology. Reviews and original manuscript contributions may focus on heart valve development, homeostasis, and/or disease.

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Editors

Joshua D Hutcheson

Florida International University

Emory University

University of Toronto

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33,813 Total views

23,216 Article views

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Frontiers in Cardiovascular Medicine

Heart Valve Disease

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