One of the most important properties of the mammalian nerve system is its plasticity. Synaptic plasticity refers to the activity-dependent changes of the strength or efficacy of synaptic transmission at preexisting synapses, which involve a variety of cell biological processes such as synaptic vesicle exocytosis and endocytosis in the presynaptic membrane, trans-synaptic cell adhesion and signaling in the synaptic cleft, and neurotransmitter receptor trafficking and recycling in the postsynaptic membrane. Over the past decades, a series of protein machinery and membrane lipids responsible for the above mentioned cell biological processes have been identified, particularly those that are essential for translocation of synaptic vesicles and receptors to the pre- and post-synaptic membranes, respectively. The current challenge is to detail the molecular mechanisms by which vesicular trafficking and protein translocation are dynamically regulated and/or modulated in response to a variety of external stimulus.
This Research Topic aims to gather research about the molecular machinery and mechanisms underlying vesicular trafficking and protein translocation in synaptic transmission and plasticity. We welcome Original Research articles. Reviews should be discussed with the Topic Editors before submission. Areas to be covered in this Research Topic may include, but are not limited to:
Main topic:
-Studies on the molecular mechanisms underlying vesicular trafficking and protein translocation in synaptic transmission and plasticity.
The following subtopics will also be welcome if related to trafficking processes:
-Studies on protein structural and functional dynamics, as well as their assembly principles related to vesicular trafficking and protein translocation in synaptic transmission and plasticity.
-Studies on activity-dependent protein/lipid synthesis and modification related to vesicular trafficking and protein translocation in synaptic transmission and plasticity.
-Studies on developing novel techniques and methods for detecting the dynamics of vesicular trafficking and protein translocation in synaptic transmission and plasticity.
One of the most important properties of the mammalian nerve system is its plasticity. Synaptic plasticity refers to the activity-dependent changes of the strength or efficacy of synaptic transmission at preexisting synapses, which involve a variety of cell biological processes such as synaptic vesicle exocytosis and endocytosis in the presynaptic membrane, trans-synaptic cell adhesion and signaling in the synaptic cleft, and neurotransmitter receptor trafficking and recycling in the postsynaptic membrane. Over the past decades, a series of protein machinery and membrane lipids responsible for the above mentioned cell biological processes have been identified, particularly those that are essential for translocation of synaptic vesicles and receptors to the pre- and post-synaptic membranes, respectively. The current challenge is to detail the molecular mechanisms by which vesicular trafficking and protein translocation are dynamically regulated and/or modulated in response to a variety of external stimulus.
This Research Topic aims to gather research about the molecular machinery and mechanisms underlying vesicular trafficking and protein translocation in synaptic transmission and plasticity. We welcome Original Research articles. Reviews should be discussed with the Topic Editors before submission. Areas to be covered in this Research Topic may include, but are not limited to:
Main topic:
-Studies on the molecular mechanisms underlying vesicular trafficking and protein translocation in synaptic transmission and plasticity.
The following subtopics will also be welcome if related to trafficking processes:
-Studies on protein structural and functional dynamics, as well as their assembly principles related to vesicular trafficking and protein translocation in synaptic transmission and plasticity.
-Studies on activity-dependent protein/lipid synthesis and modification related to vesicular trafficking and protein translocation in synaptic transmission and plasticity.
-Studies on developing novel techniques and methods for detecting the dynamics of vesicular trafficking and protein translocation in synaptic transmission and plasticity.
