Metabolic Regulation in the Development of Cardiovascular Diseases

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Background

Cardiovascular disease is the first leading cause of death worldwide and it is closely related to the metabolic syndrome, in which diabetes and obesity are well-known risk factors. Intracellular metabolic pathways orchestrate cardiovascular homeostasis and participate in the development of cardiac diseases. During the development of cardiac and vascular diseases, the metabolic shift contributes to the end events of diseases. Metabolites also participate in the cardiovascular homeostasis by regulating certain protein targets or acting as regulators of epigenetics. Recently, novel metabolites and metabolite-related post-transcriptional modifications were identified in cardiovascular diseases. However, the mechanisms underlying metabolic regulation of cardiovascular diseases are not fully understood.

This Research Topic is focused on metabolic regulation of cardiovascular diseases, with the aim to shed light on the following topics. (1) Some novel metabolites (e.g. branch-chain amino acids, short-chain fatty acids) and related protein modifications have been implicated to participate in cardiovascular diseases recently. However, their roles in cardiovascular diseases are poorly understood. (2) Previous studies on metabolic regulators of cardiovascular diseases used traditional approaches. The use of current state-of-the-art approaches (e.g. metabolic flux, metabolome, scRNA-seq, ATAC-seq, single-cell Chip-seq) could help understand how different metabolic regulators/metabolites cooperate to regulate cardiovascular diseases. (3) Several studies focus on the metabolic regulation of cardiomyocytes/endothelial cells/smooth muscle cells per se, whereas the local microenvironment is also relevant for cardiac physiological and pathological progress. Thus, novel findings on how metabolic regulators control microenvironment to regulate cardiovascular diseases are welcome in this collection. (4) Cardiac diseases are affected by peripheral organs, such as the kidney, lungs, and the gut. Hence, understanding how metabolic regulators modulate these tissues to target the heart is part of our goals.

In particular, we welcome Original Research, Reviews, Methods and other article types falling under the following points:

• Novel metabolites and related modifications in cardiovascular diseases.
• Application of state-of-the-art approaches to understand the metabolic regulation of cardiovascular diseases.
• Metabolic regulation of myocardial and vascular microenvironment.
• Metabolic/gut microbiota regulation of peripheral organs, kidneys, lungs and the gut to affect the heart and vessels.
• Novel models of cardiovascular diseases.
• Mitochondria communication with endoplasmic reticulum and nucleus in cardiovascular diseases.

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