About this Research Topic
The eradication of biofilm-related infections relies mainly on antibiotic treatments or, for antibiotic-refractory biofilm-related infections, on surgical interventions, whenever the source of infection is known. In the last years, novel and alternative methods, in addition to the standard prevention (local disinfection), have been proposed to prevent and treat biofilm infections (e.g. antibiotic-coated implanted devices, antibiotic-loaded microbubbles). Understanding the cellular and molecular mechanisms of biofilm-related infections is of great importance in the development of new treatments. Several novel in vitro models for biofilm formation attempt to reproduce the real world, for instance, by including host cells, like platelets and/or neutrophils in their system. In such settings, the mechanism of resistance of clinical microbial isolates can be studied and antibiotics cocktails can be in vitro-tested to propose the suited treatment to the patient in a reasonable time frame.
In this context, the aim of this Research Topic is to gather Original Research and Review articles centered on cellular and molecular mechanisms involved in the pathogenesis of biofilm-related infections, and how this knowledge can be exploited to improve treatments and prevention, with particular interest in infective endocarditis.
Specific areas to cover may include, but are not limited to:
1) Pathogenesis of biofilm-related infections
• Cardiac device-related infective endocarditis
• Host-bacteria interactions in infective endocarditis
• Host-predisposition to infective endocarditis
2) Therapeutic strategies to overcome antibiotic resistance
• Role of antiplatelet agents in infective endocarditis
• From preclinical models to therapeutic strategies
• Novel approaches, beyond antibiotics and prevention of biofilm formation
The image has been developed in collaboration with Alex Hego.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.