Programming HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation

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Nikolaos P Daskalakis

Harvard Medical School

Icahn School of Medicine at Mount Sinai

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Experiences during early life program the central nervous and endocrine –systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focuses on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We welcome all research or conceptual articles, review papers, brief communications, and commentary on topics related to HPA-axis programming.

Experiences during early life program the central nervous and endocrine –systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focuses on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We welcome all research or conceptual articles, review papers, brief communications, and commentary on topics related to HPA-axis programming.

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Editors

Nikolaos P Daskalakis

Harvard Medical School

Icahn School of Medicine at Mount Sinai

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Frontiers in Endocrinology

Neuroendocrine Science

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Frontiers in Neuroscience

Neuroendocrine Science

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