Therapeutic Opportunities and Innovative Biomarkers in Tumor Microenvironment

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Editorial

30 November 2021

Editorial: Therapeutic Opportunities and Innovative Biomarkers in Tumor Microenvironment

Kexin Xu

,

Farah Rahmatpanah

and

Zhenyu Jia

1,874 views

3 citations

Editors

3

University of California, Riverside

The University of Texas Health Science Center at San Antonio

Farah Rahmatpanah

University of California, Irvine

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Tumor microenvironment (TME), known as a battlefield between the cancer cells and host immune system, plays an indispensable role in cancer progression and metastasis. Studies focusing on TME have significantly improved our understanding of cancer biology, helped identify diagnostic or prognostic biomarkers, and provided novel anticancer targets. However, this research field is relatively new and thus understudied. For example, de novo or acquired resistance to drugs targeting TME is frequently observed in many types of cancer, and unfortunately not many clinically useful TME-based biomarkers have been developed to help stratify patients who may benefit from the immunotherapy. Therefore, it is urgent to deepen our knowledge of how TME works and to brainstorm ideas of effectively targeting TME for cancer therapy.

This Research Topic welcomes Original Research and Review Articles that focus on the following research areas in TME:

(1) Novel strategies for blocking tumor-promoting effects of TME or synergizing with currently available agents that modulate TME.
(2) Innovative TME biomarkers for cancer diagnosis or prognosis, or for predicting responses of cancer cells to certain TME-targeting treatment.
(3) Advanced methodologies or tools, such as three-dimensional organoids and multi-omics approaches, to comprehensively investigate the roles of TME in cancer progression and metastasis.

Tumor microenvironment (TME), known as a battlefield between the cancer cells and host immune system, plays an indispensable role in cancer progression and metastasis. Studies focusing on TME have significantly improved our understanding of cancer biology, helped identify diagnostic or prognostic biomarkers, and provided novel anticancer targets. However, this research field is relatively new and thus understudied. For example, de novo or acquired resistance to drugs targeting TME is frequently observed in many types of cancer, and unfortunately not many clinically useful TME-based biomarkers have been developed to help stratify patients who may benefit from the immunotherapy. Therefore, it is urgent to deepen our knowledge of how TME works and to brainstorm ideas of effectively targeting TME for cancer therapy.

This Research Topic welcomes Original Research and Review Articles that focus on the following research areas in TME:

(1) Novel strategies for blocking tumor-promoting effects of TME or synergizing with currently available agents that modulate TME.
(2) Innovative TME biomarkers for cancer diagnosis or prognosis, or for predicting responses of cancer cells to certain TME-targeting treatment.
(3) Advanced methodologies or tools, such as three-dimensional organoids and multi-omics approaches, to comprehensively investigate the roles of TME in cancer progression and metastasis.

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Editors

University of California, Riverside

The University of Texas Health Science Center at San Antonio

Farah Rahmatpanah

University of California, Irvine

Impact

134,579 Total views

81,526 Article views

51,154 Article downloads

1,899 Topic views

Published In

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Frontiers in Oncology

Molecular and Cellular Oncology

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Frontiers in Cell and Developmental Biology

Molecular and Cellular Oncology

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