The Serpin Family in the Cardiovascular System

96.5K

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14

articles

The Serpin Family in the Cardiovascular System

96.5K

views

14

articles

Editorial

02 February 2022

Editorial: The Serpin Family in the Cardiovascular System

Marie-Christine Bouton

,

Javier Corral

and

Alexandra R. Lucas

2,258 views

1 citations

Editors

3

Marie-Christine BOUTON

Institut National de la Santé et de la Recherche Médicale (INSERM)

Javier Corral

University of Murcia

Alexandra R Lucas

The Biodesign Institute, Arizona State University

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About

The serpin (SERine Protease INhibitor) superfamily gathers hundreds of proteins linked by a common tertiary fold. Serpins with or without inhibitory activity are involved in the regulation of a wide range of biological processes including blood coagulation, fibrinolysis, apoptosis, cell migration or inflammatory responses, which make them key factors in the pathophysiology of cardiovascular diseases such as atherosclerosis. Moreover, artificial serpins have been recently developed as therapeutic drugs with potential relevance in different disorders including cardiovascular medicine.

The aim of this research topic is to review the current knowledge and the recent advances on the role of serpins with and without antiprotease activities in cardiovascular diseases and their treatment, in particular regarding their role played in the interactions between coagulation factors- inflammatory- and vascular cells.

The scope of the Research Topic and specific themes for authors to address include:
1) Serpins in thrombosis and homeostasis.
2) Artificial serpins with therapeutic usefulness.
3) Serpins and apoptotic and inflammatory vascular responses.
4) Viral serpins and cardiovascular diseases.
5) Oxidative stress, lipids and serpins.

All types of article types will be considered for publication: original basic science reports, reviews, methodology papers, and clinical studies.

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Editors

Marie-Christine BOUTON

Institut National de la Santé et de la Recherche Médicale (INSERM)

Javier Corral

University of Murcia

Alexandra R Lucas

The Biodesign Institute, Arizona State University

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96,475 Total views

75,163 Article views

19,750 Article downloads

1,562 Topic views

Published In

Frontiers in Cardiovascular Medicine

Atherosclerosis and Vascular Medicine

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