Therapeutic Strategies in EGFR Mutant Lung Cancer

127.5K

views

218

authors

26

articles

Therapeutic Strategies in EGFR Mutant Lung Cancer

127.5K

views

218

authors

26

articles

Editors

4

Yaxiong Zhang

Sun Yat-sen University Cancer Center (SYSUCC)

Tomoya Kawaguchi

Graduate School of Medicine, Osaka City University

Wenhua Liang

First Affiliated Hospital of Guangzhou Medical University

Yunpeng Yang

Sun Yat-sen University Cancer Center (SYSUCC)

Impact

Fetching...

About

Lung cancer, specifically non-small-cell lung cancer (NSCLC), remains the leading cause of cancer-related mortality worldwide. It has been shown that the EGFR-dependent pathway is activated in many patients with NSCLC. Small-molecule tyrosine kinase inhibitors (TKIs) are the preferred initial therapy for the treatment of EGFR mutant, advanced NSCLC.

First, second and third-generation EGFR-TKIs are currently approved for the treatment of patients with NSCLC that harbors a sensitizing EGFR mutation. Each TKI has its own characteristics influencing therapeutic efficacy and toxicity. While initially effective, acquired resistance to EGFR-TKI is expected and a small subset of patients exhibit primary resistance to EGFR-TKI therapy. The mechanisms underlying primary and acquired resistance to EGFR-TKI are increasingly complex, often including acquired mutations within the drug target, engagement of ‘bypass’ pathways, intra- and inter-tumoral heterogeneity, coexistent genetic alterations in other cancer-related genes, transformation to other histologic subtypes (squamous and small-cell lung cancer) and many others. A greater understanding of the underlying biology is needed to develop strategies to overcome or prevent TKI resistance. In addition, while immuno-oncology (IO) agents are emerging as an effective treatment option for many patients with NSCLC, outcomes in patients with EGFR mutant NSCLC have been disappointing. Additional research to develop IO therapeutic strategies in EGFR-mutant lung cancer is warranted.

This Research Topic is aimed at elaborating on the progress and controversy in translational and clinical research of EGFR mutant lung cancer. We welcome Original Research contributions, relevant Review articles, Perspective and Opinion articles and unique Case Reports, which are aimed at translational research, biological characteristics, genomics and transcriptomics analysis, epidemiology, diagnosis, drug resistance, new drug development, and prognosis for patients with EGFR mutant NSCLC.

Download ebook

PDF

EPUB

Share

Editors

Yaxiong Zhang

Sun Yat-sen University Cancer Center (SYSUCC)

Tomoya Kawaguchi

Graduate School of Medicine, Osaka City University

Wenhua Liang

First Affiliated Hospital of Guangzhou Medical University

Yunpeng Yang

Sun Yat-sen University Cancer Center (SYSUCC)

Impact

127,487 Total views

88,197 Article views

37,981 Article downloads

1,309 Topic views

Published In

Frontiers in Oncology

Thoracic Oncology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic