Metabolism Meets Function: The Multifaced Role of Metabolism in Cancer

204.5K

views

182

authors

24

articles

Metabolism Meets Function: The Multifaced Role of Metabolism in Cancer

204.5K

views

182

authors

24

articles

Editorial

04 May 2022

Editorial: Metabolism Meets Function: The Multifaced Role of Metabolism in Cancer

Isabella Giacomini

and

Monica Montopoli

1,867 views

0 citations

Editors

4

Andrea Morandi

University of Florence

Lorenzo Galluzzi

Weill Cornell Medicine, Cornell University

Impact

Fetching...

About

Metabolic deregulation is an established hallmark of cancer. Although it is accepted that most cancer cells consume increased amounts of glucose and amino acids to satisfy energy, and biosynthesis demands for rapid proliferation, a complex and heterogeneous metabolic scenario has been described depending on numerous variables including tumor type and stage. Importantly, the metabolic phenotype of a given tumor is largely influenced not only by the local microenvironment but also by therapeutic interventions.

Despite Warburg reporting that, even in the presence of oxygen, cancer cells show increased glycolysis funneling of only a small fraction of glucose for oxidative phosphorylation (OXPHOS), whether such metabolic deregulation is a requisite for malignant transformation, tumor progression, and resistance to treatment remains a matter of debate.

This Research Topic aims to discuss the complex aspects of metabolic deregulation in cancer cells including (but not limited to):
-metabolic reprogramming associated with cancer phenotype, either dependent or independent of oncogene or oncosuppressor addiction;
-metabolic crosstalk between the cell types that are present in the tumor microenvironment; -metabolites that could be implicated in tumor initiation and progression with a non-metabolic role (e.g. involved in epigenetic reprogramming or signaling pathways activation).

Importantly, reports discussing potential metabolic targeting approaches, either alone or in combination with the standard therapeutic regimens, will be appreciated in this Research Topic. Authors are welcome to submit original research or review articles to provide the readers with up-to-date knowledge of the role of metabolic reprogramming in supporting and driving all the aspects of cancer biology.

Download ebook

PDF

EPUB

Share

Editors

Andrea Morandi

University of Florence

Lorenzo Galluzzi

Weill Cornell Medicine, Cornell University

Impact

204,453 Total views

139,635 Article views

62,611 Article downloads

2,207 Topic views

Published In

Frontiers in Oncology

Cancer Metabolism

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic