Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology

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Editorial

30 April 2021

Editorial: Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology

Gaetano Santulli

,

Giovanni Monaco

,

Valentina Parra

and

Giampaolo Morciano

2,421 views

7 citations

Editors

4

Giampaolo Morciano

University of Ferrara

Gaetano Santulli

Albert Einstein College of Medicine

Valentina María Parra

University of Chile

Giovanni Monaco

Centre for Drug Design and Discovery

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Intracellular organelles have been traditionally viewed as individual biological entities with static morphology, organization and function. However, it is current opinion in biology that membranes of these organelles are dynamic and engage structural and functional communications each others creating new real intracellular compartments with their own pool of proteins; these contact sites are involved in multiple molecular pathways ranging from lipid metabolism, material exchange, response to cellular stress to cell death. Among intracellular organelles, mitochondria play a crucial role in cell bioenergetics and in all those pathways. They are more abundant in cardiomyocytes, constituting 35% of the total cell volume, as the heart is an organ with a high-energy demand. Thus, it is not surprising whether their dysfunction leads to cardiovascular diseases and defect in heart development and differentiation.

This Research Topic collection aims to showcase the latest findings in understanding the mechanisms and functions of mitochondrial dynamics, remodeling and inter-organelle communications (not only those involving mitochondria) in the physiopathology of the heart. We welcome Original Research and Review articles.

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Editors

Giampaolo Morciano

University of Ferrara

Gaetano Santulli

Albert Einstein College of Medicine

Valentina María Parra

University of Chile

Giovanni Monaco

Centre for Drug Design and Discovery

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143,824 Total views

108,852 Article views

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2,893 Topic views

Published In

Frontiers in Cell and Developmental Biology

Cellular Biochemistry

Frontiers in Molecular Biosciences

Cellular Biochemistry

Frontiers in Chemistry

Cellular Biochemistry

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