Nephrotic Syndrome in Children

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Editorial

24 November 2021

Editorial: Nephrotic Syndrome in Children

Sami A. Sanjad

,

Tim Ulinski

and

Bilal Aoun

6,250 views

2 citations

Editors

3

Bilal Aoun

American University of Beirut

Sami Sanjad

American University of Beirut Medical Center

Tim Ulinski

Hôpital Armand Trousseau

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About

Nephrotic syndrome is a clinical entity characterized by massive albuminuria, hypoalbuminemia and varying degrees of edema and hyperlipidemia. Although rare in occurrence (2-6/100,000 child population), it is probably the most common chronic glomerular disease observed in children.

Up to the late 1930s and early 1940s, the mortality for childhood nephrotic syndrome reached 40% -60%. With the introduction of sulfonamides and penicillin during the Second World War it dropped to 16% and subsequently, with the introduction of ACTH and corticosteroids in the early 1950s, mortality dropped to 5%.

This Research Topic for Frontiers in Pediatrics is dedicated exploring the complications associated with nephrotic syndrome in children, as well as discussing current, novel and emerging treatments. We welcome themes that include, but are not limited to, the following:

• Historical aspects of nephrotic syndrome;
• Complications associated with nephrotic syndrome (metabolic, infectious, thromboembolic, treatment related complications etc.)
• Clinical and laboratory aspects of nephrotic syndrome;
• Histopathology of nephrotic syndrome;
• Immunological aspects of nephrotic syndrome;
• The molecular and genetic basis of nephrotic syndrome;
• Conventional treatment with corticosteroids;
• Immunosuppressive agents in steroid dependent/refractory nephrotic syndrome (RNS);
• Non-specific antiproteinuric and other therapies for nephrotic syndrome;
• Investigational and novel therapies for RNS;
• Prognosis of the nephrotic syndrome.

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Editors

Bilal Aoun

American University of Beirut

Sami Sanjad

American University of Beirut Medical Center

Tim Ulinski

Hôpital Armand Trousseau

Impact

69,852 Total views

54,122 Article views

13,893 Article downloads

1,837 Topic views

Published In

Frontiers in Pediatrics

Pediatric Nephrology

Frontiers in Nephrology

Pediatric Nephrology

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