About this Research Topic
Nephrotic syndrome is a clinical entity characterized by massive albuminuria, hypoalbuminemia and varying degrees of edema and hyperlipidemia. Although rare in occurrence (2-6/100,000 child population), it is probably the most common chronic glomerular disease observed in children.
Up to the late 1930s and early 1940s, the mortality for childhood nephrotic syndrome reached 40% -60%. With the introduction of sulfonamides and penicillin during the Second World War it dropped to 16% and subsequently, with the introduction of ACTH and corticosteroids in the early 1950s, mortality dropped to 5%.
This Research Topic for Frontiers in Pediatrics is dedicated exploring the complications associated with nephrotic syndrome in children, as well as discussing current, novel and emerging treatments. We welcome themes that include, but are not limited to, the following:
• Historical aspects of nephrotic syndrome;
• Complications associated with nephrotic syndrome (metabolic, infectious, thromboembolic, treatment related complications etc.)
• Clinical and laboratory aspects of nephrotic syndrome;
• Histopathology of nephrotic syndrome;
• Immunological aspects of nephrotic syndrome;
• The molecular and genetic basis of nephrotic syndrome;
• Conventional treatment with corticosteroids;
• Immunosuppressive agents in steroid dependent/refractory nephrotic syndrome (RNS);
• Non-specific antiproteinuric and other therapies for nephrotic syndrome;
• Investigational and novel therapies for RNS;
• Prognosis of the nephrotic syndrome.
Up to the late 1930s and early 1940s, the mortality for childhood nephrotic syndrome reached 40% -60%. With the introduction of sulfonamides and penicillin during the Second World War it dropped to 16% and subsequently, with the introduction of ACTH and corticosteroids in the early 1950s, mortality dropped to 5%.
This Research Topic for Frontiers in Pediatrics is dedicated exploring the complications associated with nephrotic syndrome in children, as well as discussing current, novel and emerging treatments. We welcome themes that include, but are not limited to, the following:
• Historical aspects of nephrotic syndrome;
• Complications associated with nephrotic syndrome (metabolic, infectious, thromboembolic, treatment related complications etc.)
• Clinical and laboratory aspects of nephrotic syndrome;
• Histopathology of nephrotic syndrome;
• Immunological aspects of nephrotic syndrome;
• The molecular and genetic basis of nephrotic syndrome;
• Conventional treatment with corticosteroids;
• Immunosuppressive agents in steroid dependent/refractory nephrotic syndrome (RNS);
• Non-specific antiproteinuric and other therapies for nephrotic syndrome;
• Investigational and novel therapies for RNS;
• Prognosis of the nephrotic syndrome.
Keywords: nephrotic syndrome, pediatric nephrotic syndrome, refractory nephrotic syndrome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
