Non-coding RNAs in Head and Neck Squamous Cell Carcinoma: Functional and Clinical Implications.

118.3K

views

188

authors

26

articles

Non-coding RNAs in Head and Neck Squamous Cell Carcinoma: Functional and Clinical Implications.

118.3K

views

188

authors

26

articles

Editorial

23 December 2021

Editorial: “Non-Coding RNAs in Head and Neck Squamous Cell Carcinoma”

Wei Cao

,

Qiang Shen

and

Ming Yann Lim

1,634 views

2 citations

Editors

3

Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University

LSU Health Sciences Center New Orleans, Louisiana State University

Tan Tock Seng Hospital

Impact

Fetching...

About

In the past several years, there has been a lot of progress in revealing the mutational landscape of Head and Neck Squamous Cell Carcinoma (HNSCC). For example, a series of hotspot mutational genes such as TP53, CDKN2A, PTEN, PIK3CA, and NOTCH1 were identified and tumors can be now classified based on genomic profiling. In addition, epigenetic profiling revealed non-coding RNAs to play regulatory roles in the pathophysiological progression, including cancer.

Non-coding RNAs including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have been found to be involved in the development and progression of HNSCC and partially associated with locoregional lymph node metastasis, local recurrence and poor, overall survival of HNSCC patients. For instance, the HOTAIR lncRNA acts as a scaffold for histone modification complexes to regulate gene expression through histone tail methylation and its overexpression was correlated with metastasis and poor prognosis in patients with HNSCC.

The aim of the Research Topics is to provide the reader with a comprehensive insight as to how non-coding RNA plays an important role in proliferation, epithelial-mesenchymal transition (EMT), autophagy, drug resistance and tumor microenvironment of Head and Neck Cancer. We welcome Original Research and Review articles describing, but not limited to, the following subtopics:

1. Non-coding RNAs and the proliferation of HNSCC cells
2. Role of non-coding RNAs in the EMT of HNSCC cells.
3. Prognostic and/or predictive factors of non-coding RNAs for patients with HNSCC.
4. Role of non-coding RNAs in the process of autophagy in HNSCC cells
5. Non-coding RNAs mediated drug resistance of patients with HNSCC
6. Non-coding RNAs in the tumor microenvironment of HNSCC

In the past several years, there has been a lot of progress in revealing the mutational landscape of Head and Neck Squamous Cell Carcinoma (HNSCC). For example, a series of hotspot mutational genes such as TP53, CDKN2A, PTEN, PIK3CA, and NOTCH1 were identified and tumors can be now classified based on genomic profiling. In addition, epigenetic profiling revealed non-coding RNAs to play regulatory roles in the pathophysiological progression, including cancer.

Non-coding RNAs including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have been found to be involved in the development and progression of HNSCC and partially associated with locoregional lymph node metastasis, local recurrence and poor, overall survival of HNSCC patients. For instance, the HOTAIR lncRNA acts as a scaffold for histone modification complexes to regulate gene expression through histone tail methylation and its overexpression was correlated with metastasis and poor prognosis in patients with HNSCC.

The aim of the Research Topics is to provide the reader with a comprehensive insight as to how non-coding RNA plays an important role in proliferation, epithelial-mesenchymal transition (EMT), autophagy, drug resistance and tumor microenvironment of Head and Neck Cancer. We welcome Original Research and Review articles describing, but not limited to, the following subtopics:

1. Non-coding RNAs and the proliferation of HNSCC cells
2. Role of non-coding RNAs in the EMT of HNSCC cells.
3. Prognostic and/or predictive factors of non-coding RNAs for patients with HNSCC.
4. Role of non-coding RNAs in the process of autophagy in HNSCC cells
5. Non-coding RNAs mediated drug resistance of patients with HNSCC
6. Non-coding RNAs in the tumor microenvironment of HNSCC

Download ebook

Share

Editors

Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University

LSU Health Sciences Center New Orleans, Louisiana State University

Tan Tock Seng Hospital

Impact

118,310 Total views

82,027 Article views

31,892 Article downloads

4,391 Topic views

Published In

Journal Thumbnail

Frontiers in Oncology

Head and Neck Cancer

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic