Recent Advances in the Immunology of Helminth Infection – Protection, Pathogenesis and Panaceas

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Editorial

17 March 2021

Editorial: Recent Advances in the Immunology of Helminth Infection – Protection, Pathogenesis and Panaceas

Kara J. Filbey

,

Constance A. M. Finney

,

Paul R. Giacomin

and

Mark C. Siracusa

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1 citations

Editors

4

Kara Filbey

The University of Manchester

Constance Finney

University of Calgary

Paul Giacomin

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, Division of Tropical Health and Medicine, James Cook University

Mark C. Siracusa

Rutgers Biomedical and Health Sciences, Rutgers, The State University of New Jersey

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Helminth infection is well known to elicit strong type-2 responses, both innate and adaptive, at local and distal sites to the parasites themselves. Alongside this, the induction of regulatory immune responses has led to a significant effort to identify particular immunomodulatory helminth products and to assess the effect of helminth infection on the microbiome, on concurrent infections and on inflammatory disease phenotypes. Indeed, research into the impact of live helminth therapy is ongoing across the globe.

Conversely, with a large number of people still suffering the detrimental effects of helminth infection on health, development and economic well-being, efforts into the development of vaccines/effective medications to eliminate these infections are pertinent.

Building on several decades of helminth immunology research, the field is ever-expanding, and recent technological developments are allowing a more detailed and in-depth analysis of the immune responses elicited by helminth infections. It is also apparent that helminth infection can be used as a useful tool to explore areas previously understudied by immunologists and allow cross-talk between traditionally separate research areas, including nutrition, metabolism and the nervous system.

In this Research Topic, we aim to explore recent cutting-edge research covering the broad field of helminth immunology. We welcome the submission of Original Research articles, Reviews, Methods and Perspectives focusing on the following subtopics:

• The immune interface between parasite and host (in model animal and human infection settings).
• Immunomodulation by helminths and the identification of novel molecular helminth products with their impact on bystander responses.
• Immunological outcomes of clinical trials and helminth-associated therapies.

Dr. Paul Giacomin is a co-founder of Paragen Bio. Dr. Siracusa is the founder and president of Nemagen Discoveries. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

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Editors

Kara Filbey

The University of Manchester

Constance Finney

University of Calgary

Paul Giacomin

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, Division of Tropical Health and Medicine, James Cook University

Mark C. Siracusa

Rutgers Biomedical and Health Sciences, Rutgers, The State University of New Jersey

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Published In

Frontiers in Immunology

Microbial Immunology

Frontiers in Microbiology

Microbial Immunology

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