Novel Molecular Targets and Treatments for Gastroesophageal Cancer

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Editorial

13 May 2022

Editorial: Novel Molecular Targets and Treatments for Gastroesophageal Cancer

Alfred King-yin Lam

,

Bin Li

,

Linhui Liang

,

Jianjun Xie

and

Wen Wen Xu

1,786 views

1 citations

Editors

5

Jinan University

Alfred King-yin Lam

School of Medicine and Dentistry, Griffith Health, Griffith University

Fudan University

College of Medicine, Shantou University

Jinan University

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Gastroesophageal cancer is among the most common malignant diseases worldwide and is associated with high mortality rates, leading to a substantial burden on public health and healthcare systems around the world. Chemotherapeutic drugs have achieved great success in the treatment of esophageal cancer; however, they also bring cytotoxicity to other organs and often have serious side effects. With the development of molecular diagnostics and biomarker discovery, the application of precision medicine has emerged to improve clinical outcomes.

New antineoplastic therapy development is a timely topic in light of the recent development of precision medicine. New biotherapies aim to inhibit or regulate different targets, which are thought to be functionally selective or overexpressed in some types of tumors. In particular, progress has been made to understand the molecular biology of gastrointestinal cancer, resulting in the discovery of various molecular targets, such as KRAS, PD-1, PD-L1, EGFR, HER2 and VEGF. Moreover, anticancer agents, such as pembrolizumab, olaparib, trastuzumab, bevacizumab, either as single agents or in combination with conventional chemotherapy, have become part of the standard of care for treatment of advanced gastroesophageal cancer.

This Research Topic provides a platform for recent studies on novel molecular targets and treatments for gastroesophageal cancer. Both Original Research articles and Reviews are welcome. Subjects may include but are not limited to:

1) Oncogenes and tumor suppressors;
2) Drug sensitivity/resistance;
3) Tumor metastasis and tumor microenvironment;
4) Biomarker discovery and epigenetic regulation.

Gastroesophageal cancer is among the most common malignant diseases worldwide and is associated with high mortality rates, leading to a substantial burden on public health and healthcare systems around the world. Chemotherapeutic drugs have achieved great success in the treatment of esophageal cancer; however, they also bring cytotoxicity to other organs and often have serious side effects. With the development of molecular diagnostics and biomarker discovery, the application of precision medicine has emerged to improve clinical outcomes.

New antineoplastic therapy development is a timely topic in light of the recent development of precision medicine. New biotherapies aim to inhibit or regulate different targets, which are thought to be functionally selective or overexpressed in some types of tumors. In particular, progress has been made to understand the molecular biology of gastrointestinal cancer, resulting in the discovery of various molecular targets, such as KRAS, PD-1, PD-L1, EGFR, HER2 and VEGF. Moreover, anticancer agents, such as pembrolizumab, olaparib, trastuzumab, bevacizumab, either as single agents or in combination with conventional chemotherapy, have become part of the standard of care for treatment of advanced gastroesophageal cancer.

This Research Topic provides a platform for recent studies on novel molecular targets and treatments for gastroesophageal cancer. Both Original Research articles and Reviews are welcome. Subjects may include but are not limited to:

1) Oncogenes and tumor suppressors;
2) Drug sensitivity/resistance;
3) Tumor metastasis and tumor microenvironment;
4) Biomarker discovery and epigenetic regulation.

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Editors

Jinan University

Alfred King-yin Lam

School of Medicine and Dentistry, Griffith Health, Griffith University

Fudan University

College of Medicine, Shantou University

Jinan University

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89,097 Total views

56,139 Article views

30,367 Article downloads

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Frontiers in Oncology

Gastrointestinal Cancers: Gastric and Esophageal Cancers, Gastrointestinal Cancers

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