Beta Amyloid: From Physiology to Pathogenesis

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71

authors

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articles

Beta Amyloid: From Physiology to Pathogenesis

90K

views

71

authors

15

articles

Editorial

14 March 2022

Editorial: Beta Amyloid: From Physiology to Pathogenesis

Robert A. Nichols

,

Walter Gulisano

and

Daniela Puzzo

2,471 views

6 citations

Editors

3

Robert A Nichols

University of Hawaii at Manoa

Daniela Puzzo

University of Catania

Walter Gulisano

Novo Nordisk (Denmark)

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Amyloid-beta (Aß) has been primarily studied as a pathogenetic factor in Alzheimer’s disease (AD). However, Aß exerts multiple physiological actions, including the regulation of synaptic activity, excitability, memory formation, microtubule dynamics, glial regulation, and neuro-immune response. How the physiological actions of Aß relate to AD pathogenesis remains to be fully elucidated. Nonetheless, a growing understanding of Aß biology and physiology has informed the development of novel AD therapeutics.

Aß is endogenously present at low levels (pM – nM) in the hippocampus and cortex, regions of the brain that undergo neurodegeneration in AD. Moreover, the levels of Aß are dynamically regulated by synaptic activity, which in turn can regulate synaptic plasticity and process underlying memory, leading to the suggestion that Aß functions as a neuropeptide.

For this Research Topic, current advances in understanding Aß biology and physiology and their relation to AD pathogenesis will be presented. Areas to be covered include:

• Synaptic plasticity – synaptic dysfunction
• Regulation of circuit excitability - hyperexcitability
• Microtubule dynamics – altered axonal transport
• Regulation of glial function – microglia in synaptic pruning
• Regulation of glia phenotypes – glial overactivation

We primarily welcome Original Research articles, Reviews, and Mini Reviews on the above themes and other areas related to the Research Topic.

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Editors

Robert A Nichols

University of Hawaii at Manoa

Daniela Puzzo

University of Catania

Walter Gulisano

Novo Nordisk (Denmark)

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90,013 Total views

66,984 Article views

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Published In

Frontiers in Molecular Neuroscience

Molecular Neuroscience Archive, Brain Disease Mechanisms, Molecular Signalling and Pathways, Methods and Model Organisms, Pain Mechanisms and Modulators, Neuroplasticity and Development

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