Critical Complications In Pediatric Oncology and Hematopoietic Cell Transplant

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Editorial

22 February 2023

Editorial: Critical complications in pediatric oncology and hematopoietic cell transplant – how far we have come and how much further we must go

Asya Agulnik

,

Kris M. Mahadeo

,

Marie E. Steiner

and

Jennifer Ann McArthur

1,320 views

1 citations

Editors

4

Asya Agulnik

St. Jude Children's Research Hospital

Jennifer Ann McArthur

St. Jude Children's Research Hospital

Kris Michael Mahadeo

Duke University

Marie E Steiner

University of Minnesota Children's Hospital

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About

Pediatric oncology and hematopoietic cell transplant (HCT) patients with a critical illness are a particularly challenging population with a unique presentation, diagnosis, and management. One in every three to four children with cancer will require admission to the Pediatric Intensive Care Unit (PICU) during the course of their treatment. Providing optimum care for these patients involves dedicated multidisciplinary collaboration to provide timely and appropriate management. Onco-critical care is a growing field of expertise for the care of this high acuity patient population. Recent work in this field has focused on sepsis, respiratory complications, and multi-organ failure in HCT patients, demonstrating significantly higher morbidity and mortality compared to other critically ill pediatric patients.

For the past decade, the HCT/oncology subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network has fostered both research and clinical collaborations between oncologists, transplanters, and critical care physicians with the goal to improve outcomes in critically ill oncology and HCT patients. Contributors to this Research Topic will be actively recruited from this network.

This Research Topic aims to provide novel insights into the developing field of pediatric onco-critical care and to stimulate further discussion in this emerging yet important field of research. We would like to include Original Research and Review articles that focus on pathophysiology, diagnosis, treatment, and outcomes of critical complications in pediatric oncology and HCT patients. Topics will include both basic science and clinical research with a strong focus on, but not limited to, the following:

1) Endothelial dysfunction and its role in complications of HCT
2) Respiratory complications of HCT
3) Thrombotic microangiopathy
4) Veno-occlusive disease
5) Long-term outcomes
6) Organ failure and management
7) CAR T-Cell therapy
8) Sepsis and infectious complications
9) Implications for resource-limited settings
10) International collaborations in Pediatric Onco-Critical Care
11) Hemophagocytic lymphohistiocytosis and Macrophage Activation Syndrome
12) The role of delirium in critical illness involving HCT and oncology patients

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Editors

Asya Agulnik

St. Jude Children's Research Hospital

Jennifer Ann McArthur

St. Jude Children's Research Hospital

Kris Michael Mahadeo

Duke University

Marie E Steiner

University of Minnesota Children's Hospital

Impact

128,398 Total views

90,119 Article views

34,758 Article downloads

3,521 Topic views

Published In

Frontiers in Oncology

Hematologic Malignancies, Pediatric Oncology

Frontiers in Pediatrics

Pediatric Oncology, Pediatric Critical Care

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With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

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