About this Research Topic

Background

Dietary fat absorption is a physiological process that governs the digestion, uptake, re-esterification, packaging, and transport of dietary fat by the small intestine to the circulatory system. The majority of the ingested lipids consist of triglycerides, cholesterols, and phospholipids. Due to the high prevalence of diabetes mellitus, obesity, and cardiovascular diseases, it is important to understand the role of dietary fat absorption in the propagation of these chronic diseases.

Although they are relatively rare, genetic abnormalities in dietary fat absorption, such as Anderson's disease, abetalipoproteinemia, and hypobetalipoproteinemia, require further study as well. Patients suffering from these genetic disorders often exhibit symptoms of malnutrition, chronic diarrhea, and hypocholesterolemia.

The understanding of dietary fat absorption can also be utilized to design a better drug delivery system, which has potential to optimize drug bioavailability and targeting, as well as food-drug interactions.

Another important research area is the development of models to study dietary fat absorption. Both in vivo and in vitro models are needed to better understand the physiology of dietary fat absorption. The ideal models should be capable of producing Apo-B48-containing chylomicrons and very low-density lipoproteins. By exploring the availability of these models we aim to facilitate research advancement in the field.

This Research Topic welcomes submissions of the following article types: Brief Research Report, Data Report, Hypothesis and Theory, Methods, Perspective, Opinion, Original Research, Mini Review, Review, and Systemic Review.

Keywords: lipid, triglyceride, chylomicron, VLDL, lipoprotein

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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