Targeting Cardiac Proteotoxicity

184.5K

views

62

authors

14

articles

Targeting Cardiac Proteotoxicity

184.5K

views

62

authors

14

articles

Editorial

25 March 2021

Editorial: Targeting Cardiac Proteotoxicity

Mark J. Ranek

,

Md. Shenuarin Bhuiyan

and

Xuejun Wang

2,296 views

1 citations

Editors

4

Xuejun Wang

Sanford School of Medicine, University of South Dakota

Hui-Hua Li

Beijing Chaoyang Hospital, Capital Medical University

Md. Shenuarin Bhuiyan

Louisiana State University Health Shreveport

Mark J. Ranek

Johns Hopkins University

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About

There is a preponderance of evidence that the progression from a large subset of human heart diseases to heart failure (HF) involves increased proteotoxic stress (IPTS); and experimental studies are demonstrating that targeting IPTS could be a novel and effective strategy for HF intervention, including both HF with reduced ejection fraction (EF) and HF with preserved EF. However, the significance of proteotoxicity in cardiac pathophysiology remains underappreciated and, importantly, none of the current clinical therapies for HF are intended to target IPTS yet, calling for increasing our effort to educate the biomedical community on this nascent and exciting field.

In the past several years, exciting new progresses have been made at multiple levels (e.g., proteomics, molecular/cell biology, and integrative physiology) regarding the underlying causes and mechanisms of action of IPTS in diseased hearts as well as novel strategies to facilitate the clearance of toxic protein species by both proteasomes and lysosomes. This Research Topic is intended to timely highlight these cutting-edge multi-disciplinary sciences, stimulate new ideas, entice more researchers to join the field, and move forward this underappreciated but highly significant field. Both Original Research and Review articles are welcomed.

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Editors

Xuejun Wang

Sanford School of Medicine, University of South Dakota

Hui-Hua Li

Beijing Chaoyang Hospital, Capital Medical University

Md. Shenuarin Bhuiyan

Louisiana State University Health Shreveport

Mark J. Ranek

Johns Hopkins University

Impact

184,466 Total views

156,643 Article views

26,455 Article downloads

1,368 Topic views

Published In

Frontiers in Physiology

Striated Muscle Physiology, Clinical and Translational Physiology

Frontiers in Cardiovascular Medicine

Heart Failure and Transplantation

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