About this Research Topic
The brain of animals and humans consists of two parts: the grey matter and the white matter. In the grey matter, neurons communicate with each other at synapses to ensure transmission and processing of neuronal information. The white matter contains axons of long-range projection neurons which propagate neuronal information over long distances to ensure correct functional connectivity between different brain areas. But is white matter simply a highway of the nervous system with little intercellular communication, or do axons send information to glial cells within the white matter tracts? Does signalling exist between different types of glia located along the axons in the white matter? How do physiological properties and communication between cells in the white matter change during diseases? What are the best approaches to study the white matter function at single-cell resolution?
Although historically interest has focused on the grey matter, in the last decade, significant progress in understanding white matter structure and function has been made: white matter tracts have been reconstructed in great details, and the previously unknown contribution of white matter pathology to aging, epilepsy, autism, mental and neurodegenerative disorders has been discovered. Although diffusion MRI still remains a major tool to study white matter in humans, in the recent years, the use of the modern electrophysiological, imaging, optogenetic, and chemogenetic approaches fostered new studies of white matter in experimental animals at single-cell resolution. New information regarding the physiological properties and function of cells composing the white matter, and the functional interaction between different cell types, is now emerging.
We are launching this research topic to highlight the recent achievements in the field, but also to emphasize the urgent need for further studies of the white matter at single-cell resolution in animal models and human patients, in parallel with functional MRI studies. This research is of primary importance for understanding the mechanisms of diseases involving the white matter, and for development of new pharmacological, genetic, and non-conventional strategies for white matter repair.
We welcome submissions of original research articles, reviews, and commentaries regarding research of white matter at the single-cell level, particularly addressing the following questions:
(1) What do recent discoveries tell us about functional role of ion channels, transporters, and receptors expressed in white matter axons and glia?
(2) How do glial cells communicate with each other and neurons, and how does this affect their function in the white matter?
(3) What role does the vasculature play in the pathogenesis of white matter damage in neurodegenerative diseases?
(4) What omic data is teaching us about the white matter?
(5) What are the best experimental and computations models to foster new discoveries about white matter function at single-cell resolution?
(6) What is the link between white matter and grey matter pathologies?
(7) Can new bioengineering approaches help restore white matter function after damage?
(8) Understanding white matter pathologies: how can clinicians and scientists help each other move forward?
(9) How are the neurodevelopmental abnormalities of white matter associated with disorders like autism, dyslexia or attention deficit hyperactivity disorder?
Although historically interest has focused on the grey matter, in the last decade, significant progress in understanding white matter structure and function has been made: white matter tracts have been reconstructed in great details, and the previously unknown contribution of white matter pathology to aging, epilepsy, autism, mental and neurodegenerative disorders has been discovered. Although diffusion MRI still remains a major tool to study white matter in humans, in the recent years, the use of the modern electrophysiological, imaging, optogenetic, and chemogenetic approaches fostered new studies of white matter in experimental animals at single-cell resolution. New information regarding the physiological properties and function of cells composing the white matter, and the functional interaction between different cell types, is now emerging.
We are launching this research topic to highlight the recent achievements in the field, but also to emphasize the urgent need for further studies of the white matter at single-cell resolution in animal models and human patients, in parallel with functional MRI studies. This research is of primary importance for understanding the mechanisms of diseases involving the white matter, and for development of new pharmacological, genetic, and non-conventional strategies for white matter repair.
We welcome submissions of original research articles, reviews, and commentaries regarding research of white matter at the single-cell level, particularly addressing the following questions:
(1) What do recent discoveries tell us about functional role of ion channels, transporters, and receptors expressed in white matter axons and glia?
(2) How do glial cells communicate with each other and neurons, and how does this affect their function in the white matter?
(3) What role does the vasculature play in the pathogenesis of white matter damage in neurodegenerative diseases?
(4) What omic data is teaching us about the white matter?
(5) What are the best experimental and computations models to foster new discoveries about white matter function at single-cell resolution?
(6) What is the link between white matter and grey matter pathologies?
(7) Can new bioengineering approaches help restore white matter function after damage?
(8) Understanding white matter pathologies: how can clinicians and scientists help each other move forward?
(9) How are the neurodevelopmental abnormalities of white matter associated with disorders like autism, dyslexia or attention deficit hyperactivity disorder?
Keywords: White matter, Astrocytes, Oligodendrocytes, Microglia, Axons
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