Mechanisms Underlying Experience-dependent Plasticity of Cortical Circuits

Editorial

30 April 2021

Editorial: Mechanisms Underlying Experience-Dependent Plasticity of Cortical Circuits

Lang Wang

Melissa L. Caras

Theofanis Karayannis

and

Robert C. Froemke

3,091 views

0 citations

Editors

University of Maryland, College Park

Theofanis Karayannis

University of Zurich

Impact

Review

10 September 2020

Shifting Developmental Trajectories During Critical Periods of Brain Formation

Nathalie Dehorter

and

Isabel Del Pino

14,278 views

91 citations

Review

17 July 2020

Silent Synapse-Based Mechanisms of Critical Period Plasticity

Weifeng Xu

, 1 more and

Oliver M. Schlüter

8,536 views

25 citations

Circuit changes during cortical maturation. (A) Rising levels of inhibitory neurotransmission are a prerequisite for onset of developmental, “passive” learning phase that occurs during the critical periods. Different types of interneurons are the source of inhibition during cortical maturation: soma-targeting Parvalbumin (PV), dendrite-targeting Somatostatin (Sst) and 5HT3-receptor+ layer I (LI) interneurons (also dendrite-targeting). It is currently unknown if and how disinhibitory vasoactive intestinal peptide (VIP) interneurons contribute to critical period plasticity. LI and Sst interneurons are sensitive to neuromodulatory inputs (spiral) before the critical period closes and robustly depolarize in response to acetylcholine (ACh) agonists or stimulation of basal forebrain. Behavioral significance of this sensitivity is yet to be defined. (B) As the cortex matures, neuromodulation-induced depolarization of 5HT3 LI and Sst interneurons is attenuated, in contrast to soma-targeting PV that begin to rapidly increase firing rate in response to cholinergic agonists. At the same time, the level of cortical inhibitory neurotransmission reaches a level that is no longer permissive for rapid circuit changes induced by passive exposure to environmental stimuli. Disinhibitory ACh-sensitive VIP and neuron-derived neurotrophic factor (NDNF)+ LI interneurons become central for plasticity and learning through the regulation of Sst and PV activity, respectively. PYR neurons are sensitive to neuromodulatory inputs throughout the lifetime.

Review

21 April 2020

Stability in the Face of Change: Lifelong Experience-Dependent Plasticity in the Sensory Cortex

Adema Ribic

7,042 views

26 citations

The neuropil response increases to the familiar visual stimulus following SRP induction. Four days of SRP induction increases the neuropil response amplitude to the familiar (X°) grating stimulus, compared to the day 1 response (paired t-test, p = 0.011). The familiar (X°) visual stimulus on day 5 evokes a higher calcium response in neuropil compared to the novel (X + 90°) visual stimulus (paired t-test, p = 0.024). Error bars indicate SEM. *p < 0.05.

Original Research

14 January 2020

Opposing Somatic and Dendritic Expression of Stimulus-Selective Response Plasticity in Mouse Primary Visual Cortex

Taekeun Kim

, 3 more and

Mark F. Bear

7,265 views

21 citations

Mini Review

28 October 2020

Engrams of Fast Learning

Charlotte Piette

, 1 more and

Laurent Venance

5,933 views

12 citations

Original Research

30 September 2020

Endocannabinoid Signaling Contributes to Experience-Induced Increase of Synaptic Release Sites From Parvalbumin Interneurons in Mouse Visual Cortex

Shiyong Huang

and

Alfredo Kirkwood

3,586 views

7 citations

Technology and Code

27 August 2020

A Primer on Constructing Plasticity Phenotypes to Classify Experience-Dependent Development of the Visual Cortex

Justin L. Balsor

, 2 more and

Kathryn M. Murphy

3,836 views

2 citations

Open for submission

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