The Role of ncRNAs in Solid Tumors Prognosis: From Laboratory To Clinical Utility

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Editorial

02 February 2021

Editorial: The Role of ncRNAs in Solid Tumors Prognosis: From Laboratory to Clinical Utility

Jian-Guo Zhou

,

Zhaohui Huang

,

Ondrej Slaby

and

Alfons Navarro

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3 citations

Editors

4

Jian-Guo Zhou

Zunyi Medical University

Zhaohui Huang

Affiliated Hospital of Jiangnan University

Ondrej Slaby

Central European Institute of Technology (CEITEC)

Alfons Navarro

University of Barcelona

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Noncoding RNAs (ncRNAs) are involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their dysregulation has been associated with the development and progression of various types of cancers, which makes them promising cancer biomarkers. In recent years, the detection of cancer-associated ncRNAs in body fluids of cancer patients has proven itself as a particularly valuable method to effectively diagnose cancer. Cancer prognosis employing circulating ncRNAs is preferential when compared to traditional tumor tissue biopsies, especially due to their noninvasiveness, and have great potential for routine application in clinical practice. Thus, this article collection focuses on summarizing the perspectives of ncRNAs as biomarkers in cancer, based on evaluating their expression profiles determined in body fluids of cancer patients.

The stability of ncRNAs in body fluids of cancer patients has not been thoroughly explored. Although several studies have demonstrated that ncRNAs, unlike lncRNAs, are highly stable under diverse temperature and storage conditions, our understanding of the former is still at the initial stages, especially for the more recently detected ncRNAs such as microRNA, lncRNAs, piRNAs, and circRNAs.

In this Research Topic, we would like to present the recent advances on the roles of ncRNAs on tumorigenesis, metastasis, chemoresistance, radioresistance as well as their potential clinical applications in solid cancers. We welcome the submission of Original Research, Review and Systematic Review articles dedicated to:

1) The mechanisms of ncRNAs in cancer development and progression
2) Large scale analysis of ncRNAs
3) Identification and validation the ncRNA prognostic model for cancers by TCGA, GEO or original data

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Editors

Jian-Guo Zhou

Zunyi Medical University

Zhaohui Huang

Affiliated Hospital of Jiangnan University

Ondrej Slaby

Central European Institute of Technology (CEITEC)

Alfons Navarro

University of Barcelona

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265,641 Total views

173,383 Article views

84,363 Article downloads

7,895 Topic views

Published In

Frontiers in Oncology

Cancer Genetics, Cancer Molecular Targets and Therapeutics

Frontiers in Pharmacology

Cancer Molecular Targets and Therapeutics

Frontiers in Genetics

Cancer Genetics

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