Mechanisms of Chronic Liver Diseases: Identifying New Therapeutic Targets

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Gianfranco Danilo Alpini

Indiana University

Heather Francis

Indiana University

Texas A&M Health Science Center, College of Medicine

Suthat Liangpunsakul

Indiana University, Purdue University Indianapolis

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Background: Chronic liver disease (CLD) is a major concern for the U.S. with the rates of morbidity and mortality on the rise since 2005. CLD includes multiple pathologies such as inflammation, fibrosis, cirrhosis and cancer, and can be induced by multiple liver disorders including hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, cholangiopathies (i.e. diseases that target the biliary epithelial cells), and others.

One of the main treatments for CLD is liver transplantation, but the number livers available for transplant is decreasing as the number of people awaiting a transplant is increasing. Therefore, it is of the utmost importance to identify new therapeutic targets for the treatment of CLD.

Details for Authors: The scope of this Research Topic is to identify new mechanisms and targets that may be therapeutics for the treatment of CLD and the various pathologies it encompasses. Papers can be more detailed and focus on a specific liver disorder or pathway, and/or be more broad to encompass multiple diseases or the targeting of an overarching process seen in liver diseases, such as mechanisms of inflammation or fibrosis. We are interested in multiple article types, ranging from original manuscripts to reviews. Overall, we would like to develop a broad research topic that can help identify new therapeutic targets for the treatment of CLD in order to aid in the progression of hepatology research and medical care.

Background: Chronic liver disease (CLD) is a major concern for the U.S. with the rates of morbidity and mortality on the rise since 2005. CLD includes multiple pathologies such as inflammation, fibrosis, cirrhosis and cancer, and can be induced by multiple liver disorders including hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, cholangiopathies (i.e. diseases that target the biliary epithelial cells), and others.

One of the main treatments for CLD is liver transplantation, but the number livers available for transplant is decreasing as the number of people awaiting a transplant is increasing. Therefore, it is of the utmost importance to identify new therapeutic targets for the treatment of CLD.

Details for Authors: The scope of this Research Topic is to identify new mechanisms and targets that may be therapeutics for the treatment of CLD and the various pathologies it encompasses. Papers can be more detailed and focus on a specific liver disorder or pathway, and/or be more broad to encompass multiple diseases or the targeting of an overarching process seen in liver diseases, such as mechanisms of inflammation or fibrosis. We are interested in multiple article types, ranging from original manuscripts to reviews. Overall, we would like to develop a broad research topic that can help identify new therapeutic targets for the treatment of CLD in order to aid in the progression of hepatology research and medical care.

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Editors

Gianfranco Danilo Alpini

Indiana University

Heather Francis

Indiana University

Texas A&M Health Science Center, College of Medicine

Suthat Liangpunsakul

Indiana University, Purdue University Indianapolis

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171,977 Article views

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Frontiers in Medicine

Gastroenterology

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