Involvement of Bioactive Peptides in the Control of Cell Survival, Proliferation and Plasticity in Physiological and Pathological Conditions

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Editorial

22 September 2021

Editorial: Involvement of Bioactive Peptides in the Control of Cell Survival, Proliferation and Plasticity in Physiological and Pathological Conditions

David Vaudry

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Dora Reglodi

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Institut National de la Santé et de la Recherche Médicale (INSERM)

University of Pécs

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During brain development, neuropeptides modulate neuron precursor proliferation, migration, differentiation and/or survival. In peripheral tissues, bioactive peptides orchestrate Sertoli cell multiplication in the testis, myocyte growth in the heart and enterocyte number in the intestine. At adulthood, neuropeptides control proliferation of neural stem cells and induce mobilization of bone marrow stem cells.

In pathophysiological conditions, certain neuropeptides are involved in Alzheimer's disease (AD) or exacerbate the deleterious effects of stroke, while others protect cell death in AD, Parkinson's disease and stroke models. Besides, bioactive peptides can stimulate ovarian cancer cell proliferation or decrease prostatic tumor growth. When the trophic effect is exerted by a protein, peptide agonists or antagonists can be designed to mimic or suppress the biological response.

These few examples, far from covering the entire field, illustrate the pleiotropic functions of peptides and their immense potential for the development of tomorrow's medicines.

The scope of this Research Topic is to highlight the involvement of peptides in the control of cell survival, proliferation and plasticity in physiological and pathological settings. Recognized experts of the different peptides in this field will be invited to write authoritative and comprehensive review articles (at least 15 review papers, each on a different peptide). In addition, we will welcome spontaneous submissions of original research manuscripts on either preclinical or translational studies.

During brain development, neuropeptides modulate neuron precursor proliferation, migration, differentiation and/or survival. In peripheral tissues, bioactive peptides orchestrate Sertoli cell multiplication in the testis, myocyte growth in the heart and enterocyte number in the intestine. At adulthood, neuropeptides control proliferation of neural stem cells and induce mobilization of bone marrow stem cells.

In pathophysiological conditions, certain neuropeptides are involved in Alzheimer's disease (AD) or exacerbate the deleterious effects of stroke, while others protect cell death in AD, Parkinson's disease and stroke models. Besides, bioactive peptides can stimulate ovarian cancer cell proliferation or decrease prostatic tumor growth. When the trophic effect is exerted by a protein, peptide agonists or antagonists can be designed to mimic or suppress the biological response.

These few examples, far from covering the entire field, illustrate the pleiotropic functions of peptides and their immense potential for the development of tomorrow's medicines.

The scope of this Research Topic is to highlight the involvement of peptides in the control of cell survival, proliferation and plasticity in physiological and pathological settings. Recognized experts of the different peptides in this field will be invited to write authoritative and comprehensive review articles (at least 15 review papers, each on a different peptide). In addition, we will welcome spontaneous submissions of original research manuscripts on either preclinical or translational studies.

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Institut National de la Santé et de la Recherche Médicale (INSERM)

University of Pécs

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Frontiers in Endocrinology

Neuroendocrine Science

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Frontiers in Neuroscience

Neuroendocrine Science

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