About this Research Topic
MiRNAs are known to control various aspects of immune response including immune signaling, immune cell differentiation and polarization. In addition to cellular miRNAs, ubiquitously secreted extracellular vesicles containing microRNAs are also acknowledged in shaping immune response/activation of recipient cells. Various pathogens, such as herpes simplex virus 1, human cytomegalovirus, etc., also encode microRNAs to counteract the host immune response. Numerous DNA viruses (predominantly herpesviruses) encode miRNAs that control virus tropism, life cycle and immune evasion.
This Research Topic aims to shed light on the role of miRNA in the recognition of various pathogens, activation of pro-inflammatory and anti-inflammatory immune pathways, differentiation and polarization of myeloid and lymphoid cells, and impact of miRNA expression profiles in infectious and inflammatory diseases (including but not limited to HIV-1, tuberculosis, rheumatoid arthritis). Additionally, studies on virus-derived microRNAs with a focus on their immune modulatory functions will also be included. We welcome the submission of Original Research articles, Reviews and Mini-Reviews covering, but not limited to, the following topics:
1. MiRNA in the regulation of immune signaling during infection and inflammation.
2. Transcriptional and post-transcriptional regulation of miRNAs in immune response.
3. MiRNA regulation of T cell and macrophage polarization and plasticity.
4. Role of miRNAs in immune cell interaction and activation during infection and inflammation.
5. Pathogen and environmental factor-mediated dysregulation of miRNA in immune response.
6. Viral-encoded miRNA in immune evasion and suppression.
7. Role of extracellular vesicles-contained microRNAs in shaping immune responses.
Keywords: microRNAs, immune signaling, polarization and plasticity, immune evasion, microRNA regulation in immunity, inflammatory and autoimmune diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.