Cytokines and Pain

  • 22k

    Total downloads

  • 80k

    Total views and downloads

Download PDFDownload EPUB

Submit your idea

Select the journal/section where you want your idea to be submitted:

Submit your manuscript summarySubmit your manuscript

About this Research Topic

Submission closed

Background

In order to survive, organisms are required to have the capacity to detect and rapidly neutralize harmful environmental challenges. In complex organisms such as mammals, two systems mediate this function - the immune system and the pain fibers from the somatosensory nervous system. Both systems contain cells that are constitutively present at tissue barriers and that are specialized to detect danger, working as sentinels of body integrity. Not surprisingly, these two systems cross-talk and modulate each other’s activity to generate cellular, molecular and behavioral responses that help to maintain homeostasis. However, If not tightly-controlled, this cross-talk can also be detrimental. Similar to prostaglandins, which are the target of non-steroidal anti-inflammatory drugs (NSAIDs) that are usually used to block inflammatory pain, cytokines are now appreciated as potential targets for pain control due to their capacity to modulate the activity of nociceptive neurons.

Cytokines are inflammatory mediators released mainly by immune cells, but also by non-immune cells, which can directly or indirectly act on nociceptive neurons, mediating pain sensation. For instance, it is well known that IL-1β , TNF-α, IL-6 and IL-17 can bind directly to their receptors expressed by nociceptive fiber terminals leading to neuronal excitability and pain sensation. Moreover, some cytokines can also release different pro-inflammatory mediators such as endothelin; chemokines; leukotrienes and prostaglandins, which can also directly or indirectly induce nociceptor sensitization. Chemokines, such as CXCL1, CCL2, CX3CL1 and their receptors are also pain mediators, facilitating the communication between neuronal and non-neuronal cells at peripheral and central levels.

As mentioned above, these different mediators can modulate pain sensitization via numerous mechanisms, including the activation of downstream signaling pathways (PKA, PKC, MAPK), modulation of ion channels activity as well as upr-egulating these channels in neuronal membranes. Thus, drugs that can block these mediators such as NSAIDs, cytokine inhibitors (e.g. anti-TNF and anti-IL-6), suppressors of cytokines signaling (as SOCS3), or even that target specific immune cells, could be an interesting approach to treat pain. On the other hand, promoting anti-inflammatory and pro-resolution mechanisms could be also an interesting tool to control pain and inflammation.

The purpose of this Research Topic is to integrate recent advances in the field of neuro-immunology that contribute to our understanding of how cytokines and other inflammatory mediators can interact with nociceptor neurons and the impact of this interaction for health and disease. We welcome the submission of Reviews and Original Research articles covering, but not limited to, the following topics:

1. The contribution of cytokines and chemokines mediating different acute and chronic pain conditions such as inflammatory, neuropathic and articular pain (e.g. osteoarthritis, rheumatoid arthritis and gout).
2. The signaling pathways involved in neuronal activation induced by cytokines and chemokines, and how these mediators can modulate non-neuronal cells, including macrophages, neutrophils, lymphocytes, glial cells, keratinocytes, among others.
3. How these mediators participate in the development and/ or maintenance of pain. Are these mediators involved in distinct stages of pain?
4. Role in modulation of ion channels and GPCR’s at peripheral and central levels.
5. Potential new analgesics targeting these proinflammatory mediators, their receptors or cells (e.g. immunobiologicals, cytokine receptor antagonists and microglial inhibitors).
6. The involvement of pro-resolution mediators, such as resolvins, maresins and protectins in pain management.
7. Induction of anti-inflammatory pathways to control pain.

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

Keywords: Society affiliation RT

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Participating Journals

Sponsorship

Impact

  • 80kTopic views
  • 55kArticle views
  • 22kArticle downloads
View impact