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EDITORIAL article

Front. Virol.
Sec. Emerging and Reemerging Viruses
Volume 4 - 2024 | doi: 10.3389/fviro.2024.1537430
This article is part of the Research Topic Unraveling Enteroviral Pathogenesis: Host Interactions and Antiviral Strategies in Asia View all 5 articles

Editorial: Unraveling Enteroviral Pathogenesis: Host Interactions and Antiviral Strategies in Asia

Provisionally accepted
Hung-Yao Ho Hung-Yao Ho *
  • Chang Gung University, Taoyuan, Taiwan

The final, formatted version of the article will be published soon.

    Enteroviruses are disease-causing pathogens. The genus Enterovirus consists of 15 species including Enterovirus A-L and Rhinovirus A-C. Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are predominant infectious agents causing hand, foot and mouth disease (HFMD). Most HFMD outbreaks have occurred in the Asia-Pacific regions that include Malaysia, Vietnam, China, and India. To date, most HFMD cases have occurred in China (1). HFMD poses persistent public health challenge, particularly in China, where its epidemiology is influenced by a multitude of factors, including environmental, social, and policy-related elements. Four articles included in this special issue provide an insight into the dynamics of HFMD However, they also raise questions about the sustainability of such approaches. China during a period from 2014 to 2017 (4). There were cyclical and seasonal changes in temporal relative risk of HFMD across different regions of mainland China.Their analysis identified southern and eastern provinces, such as Guangdong, Guangxi, and Hainan, as persistent high-risk areas, possibly owing to the favorable climatic conditions for viral transmission. Meteorological factors, like temperature, air pressure, relative humidity, and sunlight duration, increase the risk of HFMD, while higher wind speed negatively correlated with the risk. Integration of socioeconomic data revealed additional layers of complexity. Higher GDP per capita of a region was associated with lower HFMD risk, possibly indicative of allocation of more budget to disease control. High birth rate was associated with an elevated risk. This spatial heterogeneity highlights the need for the region-specific interventions tailored to local epidemiological contexts.Yuan et al. applied molecular epidemiological approach to study the HFMD distribution in Jiashan region of Zhejiang province (5). Among the enterovirus-positive specimens, the most frequently identified strains were coxsackievirus (CA) 6 (52.86%), CA16 (18.21%), EV71 (2.86%), CA10 (2.50%).Further phylogenetic analysis assigned CA16 VP1 sequences to the B1a and B1b

    Keywords: Enterovirus, Rhinovirus, Pathogenesis, host factors, Virus detection, Vaccine, antivirals

    Received: 30 Nov 2024; Accepted: 03 Dec 2024.

    Copyright: © 2024 Ho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hung-Yao Ho, Chang Gung University, Taoyuan, Taiwan

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