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CASE REPORT article

Front. Virol.
Sec. Virus and Host Immunity
Volume 4 - 2024 | doi: 10.3389/fviro.2024.1498672
This article is part of the Research Topic Innate and Adaptive/Innate Immune Responses to Viral Infection View all 7 articles

Kinetics of viral load, immunoglobulins, and cytokines of a fatal case of Crimean Congo Hemorrhagic Fever Virus

Provisionally accepted
Moufid Mhamadi Moufid Mhamadi 1*Ousseynou Sene Ousseynou Sene 2Arfang Diamanka Arfang Diamanka 3Moundhir Mhamadi Moundhir Mhamadi 4Marie Pedapa Mendy Marie Pedapa Mendy 2Andy Mahine Diouf Andy Mahine Diouf 2Mignane Ndiaye Mignane Ndiaye 2Mamadou Aliou Barry Mamadou Aliou Barry 5Samba Niang Sagne Samba Niang Sagne 5Mahfouz Cissé Traoré Mahfouz Cissé Traoré 2Amadou Alpha Sall Amadou Alpha Sall 2Gamou Fall Gamou Fall 2Ndongo Dia Ndongo Dia 2Oumar Faye Oumar Faye 2
  • 1 Virology department and Advanced vaccine bioprocessing laboratory, Institut Pasteur de Dakar, Dakar, Senegal
  • 2 virology department, Institut Pasteur de Dakar, Dakar, Senegal
  • 3 Animal Biology Department, Faculté des Sciences et Techniques, Cheikh Anta Diop University, Dakar, Dakar, Senegal
  • 4 DIATROPIX, Institut Pasteur de Dakar, Dakar, Senegal
  • 5 Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar, Senegal

The final, formatted version of the article will be published soon.

    A fatal case of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) was detected in Dakar, Senegal, West Africa, in April 2023. To elucidate the mechanisms involved in this outcome, the kinetics of viral load, immunoglobulins, and cytokines were assessed using RT-qPCR and ELISA. A high IL-6 titer, low IL-10 titer, and delayed IgG response were associated with disease severity. These biomarkers may serve as predictors of disease severity, potentially aiding in early intervention and treatment strategies.

    Keywords: CCHFV, biomarkers, Viremia, Immunoglobulins, Cytokines, severity

    Received: 19 Sep 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Mhamadi, Sene, Diamanka, Mhamadi, Mendy, Diouf, Ndiaye, Barry, Niang Sagne, Traoré, Sall, Fall, Dia and Faye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Moufid Mhamadi, Virology department and Advanced vaccine bioprocessing laboratory, Institut Pasteur de Dakar, Dakar, Senegal

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.