Skip to main content

REVIEW article

Front. Virol.
Sec. Viral Disease Investigation
Volume 4 - 2024 | doi: 10.3389/fviro.2024.1482329

Coinfection of EBV with other pathogens: A narrative review

Provisionally accepted

The final, formatted version of the article will be published soon.

    The Epstein-Barr virus (EBV) is a common herpesvirus that affects more than 90% of people worldwide. Even while EBV infections are frequently asymptomatic, they can cause autoimmune diseases and a number of cancers, especially in those with impaired immune systems. The intricate relationships between EBV and other coinfecting pathogens, including as human immunodeficiency virus (HIV), human papilloma virus (HPV), cytomegalovirus (CMV), and Plasmodium species, are examined in this study. We investigated the fundamental processes of these coinfections, their effects on the course of the disease, and their practical ramifications. The study reviewed how co-infections with EBV might modify immune responses, promote oncogenesis, and make treatment plans more challenging. In this review, we also discussed current therapeutic strategies, such as targeted molecular interventions, EBV vaccines, and adoptive T-cell therapy. The review underscores the need for more research to provide more focused and effective therapies that address the mutually reinforcing effects of numerous infections in disorders linked with EBV.

    Keywords: ebv, Coinfection, HPV, SARS-CoV-2, HHV-6, Helicobacter

    Received: 18 Aug 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Ebrahimi, Rasizadeh, Sharaflou, Shiri, Shamekh, Jafari-Sales and Bannazadeh Baghi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hossein Bannazadeh Baghi, Tabriz University of Medical Sciences, Tabriz, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.