AUTHOR=Ogalo Edith A. , Gudu Edwin , Andale Thomas , Korir Daisy , Ndege Samson , Simiyu Tabu , Olekuyo Richard , Mwangi Henry , Kimaiyo Sylvester , Aruasa Wilson 

TITLE=Clinical spectrum of COVID-19 at a national referral hospital in western Kenya during the period 2020–2021

JOURNAL=Frontiers in Virology

VOLUME=3

YEAR=2023

URL=https://www.frontiersin.org/journals/virology/articles/10.3389/fviro.2023.1202742

DOI=10.3389/fviro.2023.1202742

ISSN=2673-818X

ABSTRACT=<sec><title>Introduction</title><p>We describe the clinical spectrum of COVID-19 cases in western Kenya from 6 April 2020 to 31 May 2021, providing baseline data for further studies into COVID-19 in Kenya.</p></sec><sec><title>Methods</title><p>We did a retrospective chart review of laboratory and inpatient files of patients diagnosed and managed for COVID-19 at the Moi Teaching and Referral Hospital in Kenya and analyzed the data using Stata<sup>®</sup> version 16 (StataCorp LP, College Station, TX, USA) and calculated measures of association at 95% CI.</p></sec><sec><title>Results</title><p>The patients (<italic>n</italic> = 1,770) had a mean age of 43 years (SD 20 years) and 55.4% were male. Close to 70% had asymptomatic disease, with the symptomatic cases largely being respiratory in nature. One-quarter had comorbidities. The case fatality rate was 13.6% (<italic>n</italic> = 240). Male sex increased the odds of mortality by 1.69 (95% CI 1.27–2.25; <italic>p</italic> ≤ 0.001), and the presence of comorbidities increased the odds of mortality by 3.16 (95% CI 2.38–4.18; <italic>p</italic> ≤ 0.001). Those aged 59 years and above were 18 times more likely to die from COVID-19 than those below 15 years of age (95% CI 1.61–90.66; <italic>p</italic> = 0.015).</p></sec><sec><title>Conclusion</title><p>COVID-19 had a significantly high mortality rate in western Kenya. Male sex and the presence of comorbidities increased the risk of severe disease and mortality.</p></sec>