Septal-to-Basal Ventricular peak activation time determined by vectorcardiography as a potential new pre-screening parameter for preclinical dilated cardiomyopathy in

Margot Gheeraert ^1* Gerhard Wess ² Gitte Mampaey ¹ Jenny Eberhard ² Peter Gheeraert ¹ Jan De Pooter ¹ Luc Duchateau ¹ Pascale Smets ¹

• ¹ Ghent University, Ghent, Belgium
• ² Faculty of Veterinary Medicine, Ludwig-Maximilians-University of Munich, Munich, Bavaria, Germany

Background: Early diagnosis of preclinical dilated cardiomyopathy (DCM) remains challenging in primary veterinary medicine due to the need for echocardiography and 24-hour Holter electrocardiogram (ECG) recording. A readily available pre-screening tool to identify dogs at high risk could optimize current screening practice. Electrocardiographic methods have not been investigated for this purpose. Vectorcardiographic Septal-to-Basal Ventricular peak activation time (SB-VPAT) was investigated in a preliminary pilot study. We hypothesize that SB-VPAT is a sensitive parameter for detection of systolic dysfunction due to preclinical DCM stage B2 and correlates with left ventricular size and function in Doberman Pinschers. Animals: 122 Doberman Pinschers (98 control and 24 with systolic dysfunction due to preclinical DCM). Methods: Prospective cross-sectional study. All dogs underwent echocardiography, three-minute six or 12-lead ECG and RELF ECG. Based on echocardiographic evaluation, dogs were classified into a control group (including apparently healthy dogs and dogs with ventricular arrhythmia's only) or a group with systolic dysfunction associated with preclinical DCM stage B2. ROC curves of SB-VPAT and its correlation with left ventricular size and function were analyzed.Results: SB-VPAT ≥ 33.5 ms had a sensitivity of 94.4% and specificity of 83.6% for the detection of systolic dysfunction due to preclinical DCM stage B2 (AUC 0.954, SD 0.022). Furthermore, SB-VPAT was strongly correlated with the left ventricular systolic diameter, systolic volume index and moderately inversely correlated with EF.Conclusions and clinical importance: In conclusion, SB-VPAT is a sensitive parameter to detect systolic dysfunction associated with preclinical DCM stage B2. Further investigation of its diagnostic potential compared to or in combination with other tools in a primary care veterinary setting is warranted.