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ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Anesthesiology and Animal Pain Management
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1581490
Musculoskeletal Adverse Events in Dogs Receiving Bedinvetmab (Librela)
Provisionally accepted
Mike Farrell 1*
Felix W.A. Waibel 2 Ines Carrera 3* Giliola Spattini 4
Louise Clark 5* Robert J. Adams 6 Dirsko J.F. von Pfeil 7 Ricardo J.R. De Sousa 8
Diego Bobis Villagrà 9 Maria Amengual-Vila 8
Annalisa Paviotti 10
Rob Quinn 11 Justin Harper 12 Stephen P. Clarke 1 Christopher J. Jordan 13 Michael Hamilton 14 Andy P. Moores 13
Mark Irwin Greene 15- 1 Ferguson Veterinary Clinic, Glenrothes, United Kingdom
- 2 Department of Orthopaedic Surgery, Balgrist University Hospital, Zurich, Switzerland
- 3 Vetoracle Teleradiology, Diss, United Kingdom
- 4 Clinica Veterinaria Castellarano, Castellarano, Italy
- 5 Davies Veterinary Specialists, Shillington, United Kingdom
- 6 Paragon Veterinary Referrals (United Kingdom), Wakefield, United Kingdom
- 7 Small Animal Surgery Locum, PLLC, Dallas, Texas, United States
- 8 ESPEVET, Mallorca, Spain
- 9 Vets Now Limited, Dunfermline, Scotland, United Kingdom
- 10 Frank Pet Surgeons, Leeds, United Kingdom
- 11 Vita Referrals, Wetherby, United Kingdom
- 12 Texas Specialty Veterinary Services, Boerne, United States
- 13 The Moores Orthopaedic Clinic, Basingstoke, United Kingdom
- 14 Hamilton Specialist Referrals, High Wycombe, United Kingdom
- 15 Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Adverse drug reaction (ADR); adverse event (AE); adverse event report (AER); anti-NGF monoclonal antibody (aNGFmAb); computed tomography (CT); EudraVigilance database (EVD); European Board of Veterinary Specialisation (EBVS); European Medicines Agency (EMA); Food and Drug Administration (FDA); humeral condylar fracture (HCF); humeral intracondylar fissure (HIF); marketing authorization holder (MAH); magnetic resonance imaging (MRI); medial coronoid process (MCP); musculoskeletal adverse event (MSAE); musculoskeletal adverse event report (MSAER); nerve growth factor (NGF); non-steroidal anti-inflammatory drugs (NSAIDs); osteoarthritis (OA); rapidly progressive osteoarthritis (RPOA); risk evaluation and mitigation strategy (REMS); tibial plateau leveling osteotomy (TPLO); Veterinary Dictionary for Drug-Related Adverse Reactions (VeDDRA); Veterinary Medicines Directorate (VMD).
Keywords: bedinvetmab, Librela, NGF, Rapidly progressive osteoarthritis, RPOA Author 1. Final proof-reading: All authors
Received: 22 Feb 2025; Accepted: 04 Apr 2025.
Copyright: © 2025 Farrell, Waibel, Carrera, Spattini, Clark, Adams, von Pfeil, De Sousa, Villagrà, Amengual-Vila, Paviotti, Quinn, Harper, Clarke, Jordan, Hamilton, Moores and Greene. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mike Farrell, Ferguson Veterinary Clinic, Glenrothes, United Kingdom
Ines Carrera, Vetoracle Teleradiology, Diss, United Kingdom
Louise Clark, Davies Veterinary Specialists, Shillington, SG5 3HR, United Kingdom
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