94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Comparative and Clinical Medicine
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1570349
Amlodipine improves symmetric dimethylarginine in dogs with chronic kidney disease
Provisionally accepted
Shohei Morita1
Youhei Mochizuki2
Takahiro Kondo1Yasuyoshi Matsuda1
Takahiro Ohmori1
Aritada Yoshimura1
Ryuji Fukushima1*- 1Tokyo University of Agriculture and Technology, Fuchu, Japan
- 2Okayama University of Science, Okayama, Okayama, Japan
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
In canines, chronic kidney disease (CKD) is frequently associated with high blood pressure.Amlodipine is used to treat hypertension in dogs, and we anticipated that amlodipine administration might improve renal function in dogs. However, the effect of amlodipine on canine renal function is unknown. Therefore, this study evaluated changes in symmetric dimethylarginine (SDMA) levels before and after amlodipine administration in pet dogs that had been diagnosed with CKD based on persistently elevated SDMA levels and were being treated with amlodipine alone for any reason. We also conducted a comparative investigation of whether there were any differences in SDMA changes depending on whether these dogs with CKD had hypertension. Forty-five dogs were included in the study, of which 20 were hypertensive (HT) and 25 were non-hypertensive (Non-HT). Mean SDMA was significantly lower after drug administration compared with before administration in both the HT and Non-HT groups.Moreover, we found that cardiac output (CO) increased in all dogs with CKD treated with amlodipine. It is believed that the increase in CO due to amlodipine administration increases glomerular filtration rate, which may have led to a decrease in SDMA levels. Blood pressure measurements showed that the blood pressure decreased in both the HT and Non-HT groups.Based on the rate of decrease in systolic arterial pressure (SAP), we considered that amlodipine might decrease blood pressure by a greater amount in patients with higher levels of hypertension.In this study, we showed that amlodipine administration improved SDMA in dogs with CKD regardless of whether they were hypertension. We also showed that amlodipine could be safely used to treat normotensive dogs. KEY WORD 5-8 word amlodipine, blood pressure, chronic kidney disease, dog, hypertension, SDMA
Keywords: Amlodipine, Blood Pressure, Chronic Kidney Disease, dog, Hypertension, SDMA
Received: 03 Feb 2025; Accepted: 11 Apr 2025.
Copyright: © 2025 Morita, Mochizuki, Kondo, Matsuda, Ohmori, Yoshimura and Fukushima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ryuji Fukushima, Tokyo University of Agriculture and Technology, Fuchu, Japan
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.