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BRIEF RESEARCH REPORT article
Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1562325
This article is part of the Research Topic Natural Compounds/Products and Livestock Productivity: Enhancing Antioxidant Levels, Gut Health, Mitigating Greenhouse Gas Emissions, and Disease Control View all 27 articles
Effect of Biotin on Growth Performance, Serum Biochemical Profiles, and Histomorphological Changes in Acetate Gossypol-Treated Mice
Provisionally accepted- 1 Xinjiang Key Laboratory of Herbivore Nutrition for Meat ＆ Milk, Urumqi, China
- 2 Research Center for Biofeed and Animal Gut Health, Urumqi, China
- 3 College of Animal Sciences, Xinjiang Agricultural University, Urumqi, China
- 4 Xinjiang Key Laboratory of Herbivore Nutrition for Meat ＆ Milk, Urümqi, China
- 5 Research Center for Biofeed and Animal Gut Health, Urümqi, China
- 6 College of Animal Sciences， Xinjiang Agricultural University, Urümqi, China
The objective of this study was to determine the effects of biotin on growth performance, serum biochemical profiles, and morphology of acetate gossypol-treated mice. Seventy-five healthy male Kunming mice were randomly assigned to five treatment groups: the control group (C), the biotin control group (BC), the acetate gossypol control group (AGC), the biotin prevention group (BP) and the biotin treatment group (BT). The study examined the growth performance, visceral index, serum biochemical profiles and histomorphological changes of mice. The results showed that compared with AGC group mice, the average daily feed intake of BP group and BT group increased by 40.47% and 45.69% (P < 0.05). Biotin prevention reduced the elevated blood urea nitrogen (BUN) levels in acetate gossypol-treated mice, biotin treatment reduced the elevated serum aspartate aminotransferase (AST) , total protein (TP) and BUN levels in acetate gossypol-treated mice (P < 0.05). Biotin increase the values of villus height/crypt depth in duodenum and jejunum (P < 0.05).In conclusion, biotin potentially increase the growth performance of acetate gossypol-treated mice, it also has a positive effect on serum biochemical profiles, and histomorphological of acetate gossypol-treated mice.
Keywords: Acetate gossypol, Biotin, growth performance, Serum biochemical profiles, Histomorphological
Received: 17 Jan 2025; Accepted: 28 Mar 2025.
Copyright: © 2025 Luo, Xu, Ainiwaer, Fan and wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
caidie wang, Xinjiang Key Laboratory of Herbivore Nutrition for Meat ＆ Milk, Urumqi, China
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