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ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1560806
Evaluation of hydrolyzed salmon and hydrolyzed poultry feather diets in restrictive diet trials for diagnosis of food allergies in pruritic dogs
Provisionally accepted- 1Dermatology for Animals, Gilbert, Arizona, United States
- 2College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States
- 3Blue Buffalo Co Ltd, Minneapolis, United States
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Introduction: Canine cutaneous adverse food reaction (CAFR) is a common disorder caused by abnormal and unwanted skin reactions to ingested dietary allergens. Whereas other forms of allergic dermatitis may require drug therapy, CAFR is best treated with dietary change. Therefore, early and accurate diagnosis and treatment of CAFR are critical. The gold standard test for CAFR is a 6-to 12-week elimination diet trial using limited and known hypoallergenic proteins.A multicenter, triple-blinded, randomized, crossover prospective clinical study was conducted in dogs suspected to have cutaneous adverse food reaction. The study utilized a hydrolyzed salmon (HS) diet and a hydrolyzed poultry feather (HPF) diet in separate elimination diet trials to determine if the HS diet would be efficacious and well-tolerated, compared with the established HPF diet, to diagnose and treat CAFR.Results: Fifty-seven dogs were enrolled, and 47 dogs completed the study. HS was well-tolerated, similar to HPF. Pruritus scores during the initial elimination diet trial were reduced with both diets, and dermatitis severity scores during both diet trials were reduced with both diets in the 47 dogs diagnosed with either CAFR, CAFR with atopic dermatitis (AD), or AD. Over half of the subjects diagnosed with CAFR or CAFR with AD required >4 weeks to show PVAS score decreases ≥2 or any decrease in CADESI-4 score.Discussion: HS, like HPF, presents a valuable diagnostic and treatment tool for dogs suffering from CAFR. Both hydrolyzed diets tested also improved clinical signs in dogs diagnosed with AD and may be useful adjunctive tools in the management of canine AD.
Keywords: cutaneous adverse food reaction, elimination diet trial, Hypoallergenic food, Food reaction, allergy, dog, canine
Received: 14 Jan 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Lewis, Moore, Laporte, Daristotle and Frantz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Thomas P Lewis, Dermatology for Animals, Gilbert, Arizona, United States
Leighann Daristotle, Blue Buffalo Co Ltd, Minneapolis, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.