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CASE REPORT article
Front. Vet. Sci.
Sec. Veterinary Emergency and Critical Care Medicine
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1557657
This article is part of the Research Topic Emerging Challenges in Companion Animal Toxicology View all 8 articles
Bone Marrow Toxicity Associated with Febantel Administration in a Dog: Case Report
Provisionally accepted- MSPCA-Angell, Boston, United States
Introduction: The objective of this case report is to describe a case of bone marrow suppression suspected to be secondary to febantel administration in a dog. Case summary: A 6-year-old neutered male Labrador Retriever was presented for lethargy and fever 15 days after receiving oral febantel. Pancytopenia was noted and bone marrow sampling was consistent with hypoplasia suspected to be due to the febantel administration as no other toxic insults were identified. The dog made a full recovery in about two weeks after stopping the febantel. Discussion: This is the first report of suspected bone marrow toxicity secondary to febantel administration. Febantel is metabolized to fenbendazole which has been documented as causing bone marrow toxicity in canines.
Keywords: fenbantal1, bone marrow suppression2, idiosyncratic adverse drug reaction3, pancytopenia4, Drug toxicity and adverse effect
Received: 08 Jan 2025; Accepted: 17 Mar 2025.
Copyright: © 2025 Petronzio, Carabetta and Koid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Abbey Petronzio, MSPCA-Angell, Boston, United States
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