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ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Pharmacology and Toxicology
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1551501
This article is part of the Research Topic Natural Compounds in Veterinary Therapeutics View all articles
Antiviral activity of Scutellaria baicalensis against Getah virus in vivo and in vitro
Provisionally accepted- College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
The Getah virus (GETV) is a zoonotic arbovirus causing disease in humans and animals, a member of the Alphavirus genus. Currently, approved antiviral drugs and vaccines against alphaviruses are few available. This study aimed to investigate the anti-GETV activity of the Extract of Scutellaria baicalensis Georgi (ESG) in vivo and in vitro. The main component of ESG is baicalin, which has been shown to have antiviral, antioxidant and antibacterial activity.However, the effect of baicalin against GETV remains unknown. The results showed that ESG significantly reduces the cytopathic effect of GETV on BHK-21, and can effectively reduce the viral copy number of GETV and the expression of E2 protein. It has the most prominent inhibitory effect in the virus attachment and entry stages, with IC50 values of 3.69 and 3.94 μg/mL, respectively. When the concentration was 10 μg/mL, the efficiency of inhibiting attachment reached 95.08%. Moreover, ESG could significantly reduce the peak virus copy number and shorten the low-level poisoning time of viremia caused by GETV in mice. These findings revealed that ESG can effectively inhibit GETV infection in vivo and in vitro. The results suggest that ESG is a promising candidate drug to treat or prevent GETV infection.
Keywords: antiviral, Scutellaria baicalensis Extract, Getah virus, natural compounds, Traditional Chinese Medicine
Received: 25 Dec 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Liu, wang, Shao, Zhu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhiwen Xu, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
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