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ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1546248
This article is part of the Research TopicAdvancements in Synthetic Microbiomes for Enhancing Animal HealthView all 9 articles
Transcriptomic signatures in response to antioxidants supplementation in Korean cattle beef, Hanwoo: a 7-month feeding study
Provisionally accepted
Kangwook Lee1
La Yoon Choi1
Jun Sang Ahn2Jae Yong Song2Joong Kook Park2Suk Jun Yun2Jeong Heon Lee2
Eui-Cheol Shin3
Soo-Jin Yeom4
JIANGCHAO ZHAO5
Tae Jin Cho1
Namsu Oh1
Jeong-Oh Shin6
Dahye Kim7Tae Gyun Kim8Hyung Taek Cho8Hyo Ri Shin9Young Jun Kim1
Jae Kyeom Kim1,10*- 1Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea
- 2Nonghyup Feed, Seoul, Republic of Korea
- 3Gyeongsang National University, Jinju, South Gyeongsang, Republic of Korea
- 4Chonnam National University, Gwangju, Gwangju, Republic of Korea
- 5Department of Food Science, Dale Bumpers College of Agricultural, Food and Life Sciences, University of Arkansas, Fayetteville, Arkansas, United States
- 6Soonchunhyang University, Asan, South Chungcheong, Republic of Korea
- 7National Institute of Animal Science, Rural Development Administration, Wanju, Republic of Korea
- 8The Bioinformatix, Gwangmyeong, Republic of Korea
- 9Korea University, Sejong, Republic of Korea
- 10Department of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, Delaware, United States
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The present study investigated the effects of antioxidant supplementation on the transcriptomic profiles of Hanwoo cattle during a 7-month feeding trial. Twelve castrated Hanwoo cattle were randomly assigned to two groups: a control group (CON) and a group supplemented with antioxidants (FEED), consisting of vitamin C, vitamin E, and selenium.Growth performance and carcass traits were evaluated, and liver transcriptomic changes were assessed using RNA sequencing. While no significant differences were observed in phenotypic traits such as weight gain and feed conversion ratio, transcriptomic analysis identified 641 differentially expressed genes between the CON and FEED groups. Functional enrichment analysis revealed that differentially expressed genes were mainly associated with transcription regulation, pseudouridine synthesis, and mitochondrial function. These findings suggest that antioxidant supplementation elicits significant molecular changes in the liver, particularly affecting transcriptional activity and mitochondrial processes, even in the absence of detectable phenotypic differences.
Keywords: Hanwoo cattle, Antioxidant Supplementation, Transcriptomics, RNA sequencing, Mitochondrial function
Received: 16 Dec 2024; Accepted: 18 Feb 2025.
Copyright: © 2025 Lee, Choi, Ahn, Song, Park, Yun, Lee, Shin, Yeom, ZHAO, Cho, Oh, Shin, Kim, Kim, Cho, Shin, Kim and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jae Kyeom Kim, Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea
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