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ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1546248
This article is part of the Research Topic Advancements in Synthetic Microbiomes for Enhancing Animal Health View all 5 articles
Transcriptomic signatures in response to antioxidants supplementation in Korean cattle beef, Hanwoo: a 7-month feeding study
Provisionally accepted
Kangwook Lee 1
La Yoon Choi 1
Jun Sang Ahn 2 Jae Yong Song 2 Joong Kook Park 2 Suk Jun Yun 2 Jeong Heon Lee 2
Eui-Cheol Shin 3
Soo-Jin Yeom 4
JIANGCHAO ZHAO 5
Tae Jin Cho 1
Namsu Oh 1
Jeong-Oh Shin 6
Dahye Kim 7 Tae Gyun Kim 8 Hyung Taek Cho 8 Hyo Ri Shin 9 Young Jun Kim 1
Jae Kyeom Kim 1,10*- 1 Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea
- 2 Nonghyup Feed, Seoul, Republic of Korea
- 3 Gyeongsang National University, Jinju, South Gyeongsang, Republic of Korea
- 4 Chonnam National University, Gwangju, Gwangju, Republic of Korea
- 5 Department of Food Science, Dale Bumpers College of Agricultural, Food and Life Sciences, University of Arkansas, Fayetteville, Arkansas, United States
- 6 Soonchunhyang University, Asan, South Chungcheong, Republic of Korea
- 7 National Institute of Animal Science, Rural Development Administration, Wanju, Republic of Korea
- 8 The Bioinformatix, Gwangmyeong, Republic of Korea
- 9 Korea University, Sejong, Republic of Korea
- 10 Department of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, Delaware, United States
The present study investigated the effects of antioxidant supplementation on the transcriptomic profiles of Hanwoo cattle during a 7-month feeding trial. Twelve castrated Hanwoo cattle were randomly assigned to two groups: a control group (CON) and a group supplemented with antioxidants (FEED), consisting of vitamin C, vitamin E, and selenium.Growth performance and carcass traits were evaluated, and liver transcriptomic changes were assessed using RNA sequencing. While no significant differences were observed in phenotypic traits such as weight gain and feed conversion ratio, transcriptomic analysis identified 641 differentially expressed genes between the CON and FEED groups. Functional enrichment analysis revealed that differentially expressed genes were mainly associated with transcription regulation, pseudouridine synthesis, and mitochondrial function. These findings suggest that antioxidant supplementation elicits significant molecular changes in the liver, particularly affecting transcriptional activity and mitochondrial processes, even in the absence of detectable phenotypic differences.
Keywords: Hanwoo cattle, Antioxidant Supplementation, Transcriptomics, RNA sequencing, Mitochondrial function
Received: 16 Dec 2024; Accepted: 18 Feb 2025.
Copyright: © 2025 Lee, Choi, Ahn, Song, Park, Yun, Lee, Shin, Yeom, ZHAO, Cho, Oh, Shin, Kim, Kim, Cho, Shin, Kim and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jae Kyeom Kim, Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea
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