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CASE REPORT article
Front. Vet. Sci.
Sec. Oncology in Veterinary Medicine
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1542700
This article is part of the Research Topic Cancer in Domestic, Exotic and Wild Animals: New Horizons in Tumorigenesis, Diagnosis, Prognosis and Therapeutics through Comparative Oncology View all 7 articles
Case Report: A Study on the Pathology of Mandibular Osteosarcoma with Hepatic Metastasis in a Giant Panda
Provisionally accepted
Zong-Liang Xiong 1
Shanshan Lin 2* Caiwu Li 2* Linhua Deng 2* Tingting Wei 1*
He Ming 2 Chengdong Wang 2* Desheng Li 2*
Zhengli Chen 1*- 1 Sichuan Agricultural University, Cheng Du, China
- 2 China Conservation and Research Center for the Giant Panda,Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in the Giant Panda National Park, Cheng Du, China
During routine health examinations, an abnormal growth was detected in the oral cavity of a male giant panda. A malignant tumor, osteosarcoma, was diagnosed through CT (computed tomography) scans and pathological examination of biopsy samples. After two attempts at "tumor reduction surgery" with no improvement, the condition stabilized following particle implantation and arterial infusion interventional therapy. The following year, a CT scan revealed a highly similar mass in the left lumbar muscle, which showed no improvement despite chemotherapy, leading to death one month later. Post-mortem examination and tissue pathological diagnosis confirmed osteosarcoma characteristics in the facial, lumbar, and liver masses. The giant panda was diagnosed with osteosarcoma with liver metastasis based on integrated pathological and gross anatomical observations. This case represents the first report of osteosarcoma with liver metastasis in a giant panda, providing valuable data and references for future clinical diagnosis and treatment of tumors in giant pandas.
Keywords: giant panda, Osteosarcoma, Tumor metastasis, Pathology, Cheek osteosarcoma
Received: 10 Dec 2024; Accepted: 21 Jan 2025.
Copyright: © 2025 Xiong, Lin, Li, Deng, Wei, Ming, Wang, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shanshan Lin, China Conservation and Research Center for the Giant Panda,Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in the Giant Panda National Park, Cheng Du, China
Caiwu Li, China Conservation and Research Center for the Giant Panda,Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in the Giant Panda National Park, Cheng Du, China
Linhua Deng, China Conservation and Research Center for the Giant Panda,Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in the Giant Panda National Park, Cheng Du, China
Tingting Wei, Sichuan Agricultural University, Cheng Du, China
Chengdong Wang, China Conservation and Research Center for the Giant Panda,Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in the Giant Panda National Park, Cheng Du, China
Desheng Li, China Conservation and Research Center for the Giant Panda,Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in the Giant Panda National Park, Cheng Du, China
Zhengli Chen, Sichuan Agricultural University, Cheng Du, China
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