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REVIEW article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1535328
This article is part of the Research Topic The application of new technologies such as new vaccines, therapeutic cytokines and antibodies, and antiviral drugs in the prevention and treatment of animal infectious diseases View all 13 articles
Research Advances in Replication-Deficient Viral Vector Vaccines
Provisionally accepted- 1 Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
- 2 College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang Province, China
In recent years, replication-deficient viral vector vaccines have attracted much attention in the field of vaccine research and development due to their high safety and immunogenicity. These vaccines use genetic modifications to engineer viral vectors that make them unable to replicate but effective in expressing recombinant proteins and induce immune responses. Currently, replication-deficient adenovirus vectors and poxvirus vectors are widely used in vaccine R&D for a variety of infectious diseases in humans and animals, including AIDS, hepatitis B, pseudorabies, avian influenza, infectious bronchitis in poultry, and foot-and-mouth disease. Replication-deficient viral vaccines have been shown to effectively induce neutralizing antibodies and cellular immune responses, thereby providing effective immune protection. Future development of genetic engineering technology and continuous in-depth research on viral vectors should lead to replication-deficient viral vector platforms that have an essential role in preventing and controlling existing and emerging infectious diseases.
Keywords: Replication-deficient virus, replication-deficient vaccine, Single-cycle replication, Safety, Vector, Vaccine
Received: 27 Nov 2024; Accepted: 11 Feb 2025.
Copyright: © 2025 Wang, Cui, Li and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guoxin Li, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
Lingxue Yu, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.