Skip to main content

BRIEF RESEARCH REPORT article

Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1531861

High pathogenicity of emerging porcine G9P[23] and G11P[7] rotavirus for newborn piglets in China

Provisionally accepted
Zhendong Zhang Zhendong Zhang 1*Duo Li Duo Li 2Sun He Sun He 3Jiubin Du Jiubin Du 3Yubo Li Yubo Li 2Qiangde Liu Qiangde Liu 3Pengjiang Wang Pengjiang Wang 3Wenqiang Wang Wenqiang Wang 1Wei Wen Wei Wen 1Zhenbang Zhu Zhenbang Zhu 1Xudong Tang Xudong Tang 2Xiangdong Li Xiangdong Li 1
  • 1 Yangzhou University, Yangzhou, China
  • 2 Jiangsu University of Science and Technology, Zhenjiang, Jiangsu Province, China
  • 3 TECON Biopharmaceutical Co., Ltd.,, Xinjiang, China

The final, formatted version of the article will be published soon.

    In order to better understand the pathogenicity of the current porcine A group rotavirus (PoRVA) field strains, AHBZ2304 (G9P [23]) and AHBZ2303 (G11P[7]) isolated from diarrhea suckling piglets were selected for pathogenicity analysis in the present study.Experimental inoculation of colostrum-deprived 2-day-old piglets revealed that both isolates caused severe clinical sings, high level of virus shedding and significant damage to the small intestinal villi. Additionally, both gross and microscopic lung lesions were identified at 72 hours post infection (HPI) compared to control. Alterations in the microbiota and the overexpression of inflammatory cytokines may serve as critical mechanisms driving the bowel disease associated with PoRVA infection. Our results are of great significance for understanding the pathogenicity of PoRVA emerged in recent years, highlighting the potential for porcine rotavirus to become epidemic and complex, and necessitating heightened attention of the often-overlooked disease in the field.

    Keywords: Porcine group A rotavirus, G9P[23], G11P[7], pathogenicity, piglets

    Received: 21 Nov 2024; Accepted: 04 Feb 2025.

    Copyright: © 2025 Zhang, Li, He, Du, Li, Liu, Wang, Wang, Wen, Zhu, Tang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhendong Zhang, Yangzhou University, Yangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.