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ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Volume 12 - 2025 |
doi: 10.3389/fvets.2025.1486201
Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway
Provisionally accepted- 1 Fudan University, Shanghai, China
- 2 Nourse Centre for Pet Nutrition, Wuhu, Anhui Province, China
- 3 Shanghai Chowsing Pet Products Co., Ltd. CN, Shanghai, China
- 4 Wuhu Weishi Biotechnology Co., Ltd. CN, wuhan, China
- 5 School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu Province, China
For pets, healthy hair not only represents their beautiful appearance, but also reflects their overall health status. Nutritional imbalance, skin parasites, and stress can all cause a large amount of hair loss in pets, leading to skin-related diseases and posing a threat to their health. So, it is very important to understand and find solutions to alleviate or treat pet hair loss. The Wnt/β-catenin signal plays a core role in the hair regeneration process. Here, we report that keratin hydrolyzed, egg yolk lecithin, and fish collagen peptide promote β-catenin nuclear translocation and significantly enhance the expression of their target genes in canines and cats skin cell lines, indicating that these nutrients are likely to play a beneficial role in promoting hair regeneration in canines and cats.
Keywords: Keratin hydrolyzed, Egg yolk lecithin, Fish collagen peptide, β-catenin, Hair regeneration process
Received: 25 Aug 2024; Accepted: 27 Jan 2025.
Copyright: © 2025 Lv, Sun, Gao, Ma, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lei Lv, Fudan University, Shanghai, China
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